TABLE 1.
Incidence of severe disease following single-species or polymicrobial infection in a murine model of ascending UTI
| Parameter | No. (%) of micee |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Single-species infections |
Coinfections |
Total for all infections (n = 133) | |||||||||
| P. mirabilis (n = 20) | P. mirabilis Δure (n = 11) | P. stuartii (n = 21) | P. stuartii Δure (n = 17) | Total (n = 69) | P. mirabilis + P. stuartii (n = 23) | P. mirabilis + P. stuartii Δure (n = 17) | P. stuartii + P. mirabilis Δure (n = 12) | P. mirabilis Δure + P. stuartii Δure (n = 12) | Total (n = 64) | ||
| Urine pH 8a | 7 (35) | 0 (0) | 0 (0) | 0 (0) | 7 (10) | 11 (48) | 3 (18) | 0 (0) | 0 (0) | 14 (22) | 21 (16) |
| Urolithiasisb | 1 (5) | 0 (0) | 1 (5) | 0 (0) | 2 (3) | 8 (35) | 3 (18) | 0 (0) | 0 (0) | 11 (17) | 13 (10) |
| Tissue damagec | 8 (40) | 0 (0) | 6 (29) | 2 (12) | 16 (23) | 16 (70)*** | 5 (29)*** | 3 (25) | 0 (0) | 24 (38) | 40 (30) |
| Bacteremiad | 6 (30) | 2 (18) | 4 (19) | 2 (12) | 14 (20) | 12 (52)* | 10 (59)* | 3 (25) | 4 (33) | 29 (45)* | 43 (32) |
a
Urine pH measurement of 8 or higher at any time postinoculation.
b
Assessed by gross macroscopic examination of bladder and kidneys upon euthanasia.
c
A combined histopathology score (cystitis plus pyelonephritis) of 4 or greater is indicative of moderate to severe tissue damage.
d
Assessed by spleen colonization.
e
*, P < 0.05; ***, P < 0.001. P values were determined by logistic regression.