Figure 4.

Key Figure: Summary of Ciliogenesis Regulatory Inputs

Schematic that summarizes current understanding of pathways regulating ciliogenesis. The primary cilium and regulatory interactions are depicted as in previous figures. Black lines indicate cellular inputs into ciliogenesis. Blue lines depict signals that originate in the cilium and regulate cytoplasmic processes. Orange lines are regulatory mechanisms presumably confined to the ciliary compartment. Regulatory pathways discussed in the main text include inputs from the cell cycle (‘CC’), structural influences of the actin cytoskeleton, signaling processes such as the Shh signaling pathway and processes of cellular homeostasis and proteostasis, including the lysosome-associated mTOR signaling pathway, autophagy, and the ubiquitin-proteasome system. Further transcriptional regulation of ciliogenesis is not indicated owing to space constraints.