Figure 4.
Effects of HMS5552 on GK immunoreactivity in the rat liver. Liver tissue sections stained with anti-GK antibody are shown at 200x magnification (a), and the number of GK-immunopositive cells was analyzed (b). HMS-L group, low-dose (10 mg/kg) HMS5552-treated diabetic group; HMS-H group, high-dose (30 mg/kg) HMS5552-treated diabetic group. The data are expressed as the mean ± SD (n = 6). ∗P < 0.05 and ∗∗P < 0.01, compared with the control group; ##P < 0.01, compared with the diabetic group; &&P < 0.01, compared with the HMS-L group.