Table 4.
Maternal and unit factors associated with MgSO4 treatment of women with severe pre-eclampsia, eclampsia or HELLP or fetal neuroprotection in women without pre-eclampsia, eclampsia or HELLP
| Women with severe pre-eclampsia* (255/720) |
Women without pre-eclampsia, HELLP or eclampsia (95/3658) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Receiving MgSO4 | n/N | Per cent | aOR | 95% CI | n/N | Per cent | aOR | 95% CI |
| Maternal age (years) | ||||||||
| <25 | 58/158 | 42.0 | 1.32 | (0.72 to 2.41) | 24/631 | 3.8 | 1.68 | (0.84 to 3.35) |
| 25–34 | 131/364 | 36.0 | 0.89 | (0.56 to 1.42) | 47/2044 | 2.3 | 0.86 | (0.48 to 1.55) |
| ≥35 | 64/214 | 29.9 | Ref. | 24/972 | 2.5 | Ref. | ||
| Parity | ||||||||
| Primiparous | 77/242 | 31.8 | 1.07 | (0.7 to 1.65) | 44/1690 | 2.6 | 0.84 | (0.51 to 1.36) |
| Multiparous | 177/474 | 37.3 | Ref. | 50/1944 | 2.6 | Ref. | ||
| Gestational age (weeks) | ||||||||
| 24+0–25+6 | 18/48 | 37.5 | 1.71 | (0.78 to 3.74) | 18/453 | 4.0 | 2.31 | (1.13 to 4.74) |
| 26+0–28+6 | 86/216 | 39.8 | 1.64 | (1.07 to 2.51) | 36/1148 | 3.1 | 1.71 | (1.02 to 2.86) |
| 29+0–31+6 | 151/456 | 33.1 | Ref. | 41/2057 | 2.0 | Ref. | ||
| Diagnosis of IUGR | ||||||||
| No | 161/421 | 38.2 | Ref. | 79/3173 | 2.5 | Ref. | ||
| Yes | 92/296 | 31.1 | 0.65 | (0.43 to 0.99) | 14/466 | 3.0 | 1.12 | (0.54 to 2.33) |
| Sex of baby | ||||||||
| Male | 112/329 | 34.0 | 0.89 | (0.6 to 1.32) | 54/2006 | 2.7 | 0.90 | (0.55 to 1.45) |
| Female | 143/390 | 36.7 | Ref. | 41/1652 | 2.5 | Ref. | ||
| Type of pregnancy | ||||||||
| Singleton | 13/38 | 34.2 | 1.19 | (0.47 to 3.03) | 12/811 | 1.5 | 1.80 | (0.92 to 3.54) |
| Multiple | 242/682 | 35.5 | Ref. | 83/2846 | 2.9 | Ref. | ||
| Pregnancy complications | ||||||||
| Eclampsia | 23/51 | 45.1 | 2.21 | (1.03 to 4.71) | – | – | – | – |
| HELLP | 72/198 | 36.4 | 0.60 | (0.37 to 0.97) | – | – | – | – |
| Antepartum haemorrhage | 7/26 | 26.9 | 0.49 | (0.15 to 1.56) | 23/865 | 2.7 | 0.78 | (0.44 to 1.41) |
| Admission for preterm labour | 4/35 | 11.4 | 0.18 | (0.04 to 0.7) | 51/1974 | 2.6 | 0.67 | (0.39 to 1.15) |
| PPROM | 1/5 | – | – | – | 29/1283 | 2.3 | 0.57 | (0.32 to 1.01) |
| Infection as indication for delivery | 1/1 | 100 | – | – | 14/421 | 3.3 | 1.30 | (0.64 to 2.64) |
| In utero transfer | 95/295 | 38.2 | 1.44 | (0.92 to 2.27) | 34/1242 | 2.7 | 0.78 | (0.45 to 1.36) |
| Unit polices of MgSO4 use | ||||||||
| for pre-eclampsia | ||||||||
| Whenever possible | 125/296 | 42.2 | Ref. | – | – | – | – | |
| Sometimes | 106/339 | 31.3 | 0.73 | (0.43 to 1.25) | – | – | – | – |
| Never | 0/32 | 0.0 | – | – | – | – | – | – |
| No response | 29/53 | 45.3 | 0.70 | (0.34 to 1.47) | – | – | – | – |
| for neuroprotection | ||||||||
| Whenever possible | – | – | – | – | 47/260 | 18.1 | Ref. | |
| Sometimes | – | – | – | – | 24/749 | 3.2 | 0.08 | (0.03 to 0.19) |
| Never | – | – | – | – | 14/2173 | 0.6 | 0.02 | (0.01 to 0.04) |
| No response | – | – | – | – | 10/476 | 2.1 | 0.08 | (0.03 to 0.24) |
*Defined as a diagnosis of eclampsia or HELLP, regardless of mode of delivery, or a diagnosis of pre-eclampsia and a prelabour caesarean section before 32 weeks of gestation.
HELLP, Haemolysis, elevated liver enzymes, low platelet count; IUGR, intrauterine growth restriction; PPROM, preterm prelabour rupture of membranes.
MgSO4, magnesium sulfate.