Table 3.
Crude event rates per 10 000 therapies for 14-day and 37-day all-cause mortality and CV and arrhythmia events, by first-line antibiotic monotherapy and by indication
| 14-day analysis |
37-day analysis |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CV |
Death |
Arrhythmia |
CV |
Death |
Arrhythmia |
|||||||
| Events | Crude rate | Events | Crude rate | Events | Crude rate | Events | Crude rate | Events | Crude rate | Events | Crude rate | |
| Lower respiratory tract infection | ||||||||||||
| Overall | 1102 | 15.7 | 3690 | 43.2 | 1393 | 19.3 | 2071 | 29.6 | 7401 | 86.8 | 3359 | 49.3 |
| Amoxicillin | 686 | 14.2 | 2177 | 37.3 | 948 | 19.1 | 1326 | 27.5 | 4315 | 74.0 | 2199 | 44.3 |
| Erythromycin | 92 | 14.5 | 251 | 33.5 | 97 | 15.0 | 163 | 25.7 | 469 | 62.7 | 245 | 38.1 |
| Clarithromycin | 58 | 16.4 | 225 | 52.2 | 75 | 21.1 | 103 | 29.3 | 449 | 104.6 | 197 | 55.5 |
| Co-amoxiclav | 67 | 22.7 | 302 | 81.1 | 65 | 21.1 | 118 | 40.1 | 614 | 165.2 | 188 | 61.2 |
| Cefalexin | 71 | 31.5 | 251 | 86.9 | 48 | 20.2 | 111 | 49.3 | 471 | 163.3 | 114 | 48.1 |
| Doxycycline | 25 | 15.0 | 47 | 22.7 | 37 | 22.1 | 43 | 25.9 | 122 | 59.3 | 90 | 53.9 |
| Oxytetracycline | 16 | 13.9 | 17 | 12.3 | 16 | 13.3 | 39 | 33.8 | 49 | 35.5 | 39 | 32.5 |
| Other* | 87 | 21.8 | 420 | 81.6 | 107 | 25.4 | 168 | 42.1 | 912 | 177.3 | 287 | 55.1 |
| Upper respiratory tract infections | ||||||||||||
| Overall | 350 | 5.0 | 203 | 2.7 | 555 | 8.3 | 688 | 9.9 | 591 | 7.9 | 1422 | 21.3 |
| Amoxicillin | 187 | 5.4 | 122 | 3.2 | 316 | 9.4 | 368 | 10.6 | 359 | 9.4 | 773 | 23.1 |
| Penicillin-V | 40 | 10.7 | 15 | 1.2 | 45 | 4.0 | 68 | 5.9 | 32 | 2.6 | 138 | 12.4 |
| Doxycycline | 33 | 4.9 | 10 | 1.4 | 54 | 8.4 | 71 | 10.5 | 33 | 4.6 | 140 | 21.9 |
| Erythromycin | 25 | 4.0 | 15 | 2.2 | 51 | 8.6 | 46 | 7.4 | 39 | 5.9 | 137 | 23.1 |
| Co-amoxiclav | 14 | 5.9 | 6 | 2.3 | 23 | 10.0 | 32 | 13.4 | 25 | 9.7 | 62 | 27.1 |
| Cefalexin | 12 | 5.7 | 8 | 3.4 | 25 | 12.1 | 25 | 10.6 | 27 | 11.4 | 55 | 23.3 |
| Clarithromycin | 10 | 5.3 | 5 | 2.5 | 12 | 6.8 | 23 | 11.3 | 17 | 8.4 | 43 | 24.4 |
| Other† | 29 | 2.5 | 22 | 5.3 | 29 | 8.0 | 55 | 14.8 | 59 | 14.2 | 74 | 20.4 |
| Upper and lower respiratory tract infections combined | ||||||||||||
| Overall | 1452 | 10.4 | 3893 | 24.2 | 1948 | 14.0 | 2759 | 19.8 | 7992 | 49.8 | 4781 | 34.4 |
| Amoxicillin | 873 | 10.5 | 2299 | 23.8 | 87 | 16.3 | 1694 | 20.5 | 4674 | 48.5 | 2972 | 35.8 |
| Erythromycin | 117 | 9.3 | 266 | 18.8 | 148 | 11.9 | 209 | 16.7 | 508 | 35.9 | 382 | 30.9 |
| Penicillin-V | 43 | 3.6 | 22 | 1.8 | 53 | 4.6 | 73 | 6.1 | 52 | 4.2 | 148 | 13.0 |
| Doxycycline | 58 | 6.9 | 57 | 6.1 | 91 | 11.3 | 114 | 13.5 | 155 | 16.7 | 230 | 28.6 |
| Co-amoxiclav | 81 | 15.2 | 308 | 48.8 | 81 | 15.2 | 150 | 28.1 | 639 | 101.5 | 250 | 46.6 |
| Clarithromycin | 68 | 12.6 | 230 | 36.2 | 68 | 12.6 | 126 | 23.4 | 466 | 73.7 | 240 | 45.2 |
| Cefalexin | 83 | 19.0 | 259 | 49.4 | 83 | 19.0 | 136 | 25.4 | 498 | 95.0 | 169 | 38.1 |
| Oxytetracycline | 25 | 11.4 | 18 | 7.1 | 25 | 11.4 | 53 | 24.2 | 53 | 21.0 | 55 | 24.8 |
| Other‡ | 104 | 16.2 | 434 | 55.3 | 104 | 16.2 | 204 | 31.9 | 947 | 120.7 | 335 | 51.3 |
*Forty-six antibiotics (10 most frequently used: penicillin-V, flucloxacillin, cefradine, azithromycin, tetracycline, ampicillin, cefadroxil, ofloxacin, levofloxacin, nitrofurantoin).
†Thirty-one antibiotics (10 most frequently used: ciprofloxacin, flucloxacillin, tetracycline, cefradine, cefadroxil, azithromycin, metronidazole, nitrofurantoin, ampicillin, co-fluampicil).
‡Forty-nine antibiotics (10 most frequently used: trimethroprim, cefaclor, ciprofloxacin, flucloxacillin, cefradine, tetracycline, azithromycin, ampicillin, cefadroxil, nitrofurantoin, metronidazole).
CV, cardiovascular.