. 2017 Jan 30;140(2):472–486. doi: 10.1093/brain/aww326

Table 2.

Predicting treatment response with components from ICA using linear regression (n = 29)

Variable
Targets
	*Component 1^b*			*Component 8*			*Component 16*			*Component 17*			*Component 22*
	R2	Β	P	R2	Β	P	R2	B	P	R2	B	P	R2	B	P
Full ICA sample
Event related to component	0.09	−00.19	0.38	0.06	−0.05	0.81	0.06	0.03	0.90	0.16	−0.32	0.09	0.10	−0.20	0.30
Medication		0.34	0.12		0.25	0.21		0.26	0.20		0.28	0.14		0.31	0.12
Age		0.24^a	0.30		0.29^a	0.21		0.28^a	0.23		0.28^a	0.19		0.33^a	0.13
Gender		0.10^a	0.61		0.06^a	0.76		0.08^a	0.70		0.02^a	0.90		0.12^a	0.51
Participants treated with duloxetine
Event related to component	0.04	−0.20	0.52	0.02	0.13	0.68	0.01	0.12	0.71	0.10	−0.32	0.29	0.01	−0.07	0.82
Participants treated with escitalopram
Event related to component	0.02	−0.15	0.59	0.04	−0.20	0.47	0.01	−0.07	0.79	0.11	−0.33	0.21	0.12	−0.34	0.20

Commissions
	*Component 11*			*Component 15*			*Component 17*			*Component 24*			*Component 25*
	R²	Β	P	R²	Β	P	R²	Β	P	R²	Β	P	R²	Β	P
Full ICA sample
Event related to component	0.10	−0.19	0.36	0.07	−0.05	0.80	0.08	−0.13	0.50	0.29	−0.49	0.008	0.43	−0.65	<0.001
Medication		0.32	0.12		0.25	0.19		0.28	0.16		0.35	0.048		0.48	0.006
Age		0.24^a	0.27		0.26^a	0.25		0.28^a	0.21		0.19^a	0.34		0.12^a	0.52
Gender		0.08^a	0.67		0.09^a	0.65		0.14^a	0.49		0.02^a	0.93		0.04^a	0.80
Participants treated with duloxetine
Event related to component	0.01	−0.09	0.77	0.02	0.14	0.65	0.03	−0.19	0.54	0.15	−0.38	0.20	0.29	−0.54	0.06
Participants treated with escitalopram
Event related to component	0.06	−0.25	0.35	0.02	−0.15	0.58	0.01	−0.08	0.76	0.32	−0.56	0.02	0.48	−0.69	0.003

Rejections
	*Component 11*			*Component 16*			*Component 17*			*Component 25*
	R²	Β	P	R²	Β	P	R²	Β	P	R²	Β	P
Full ICA sample
Event related to component	0.07	−0.08	0.66	0.10	0.20	0.31	0.07	−0.02	0.94	0.11	−0.33	0.08
Medication		0.25	0.21		0.31	0.13		0.25	0.21		0.34^a	0.12
Age		0.27^a	0.25		0.28^a	0.19		0.27^a	0.22		0.19^a	0.39
Gender		0.08^a	0.67		0.07^a	0.73		0.11^a	0.60		0.07^a	0.71
Participants treated with duloxetine
Event related to component	0.01	0.09	0.78	0.11	0.34	0.26	0.08	0.28	0.35	0.00	−0.04	0.90
Participants treated with escitalopram
Event related to component	0.03	−0.18	0.50	0.00	0.04	0.90	0.13	−0.36	0.18	0.43	−0.66	0.006

Variable removed from final reduced model.

Null hypothesis predictor component. Models were not corrected for multiple comparisons, but FDR corrected P-values were computed for Commission events: P-value = 0.02). Italicized P-values are significant or trending toward significance at P=0.05.