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. 2017 Jan 30;7:41660. doi: 10.1038/srep41660

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Human hepatocyte chimeric mice that experienced relapse after LDV/GS-558093 treatment and re-treatment with ASV/DCV. Serum HCV RNA levels (A). N.D., not detected, and S.D., signal detected but at lower quantification levels. Deep sequencing was performed at weeks 10 (point A), 14 (point B) and 26 (point C). The phylogenetic tree was constructed with the top 10 clusters at each time point (A1 to A10 with circles, B1 to B10 with triangles and C1 to C10 with squares) and the top cluster from the minor L31V-Y93H double substitution at week 10 (Am1) (B). *Represents the putative original cluster before ASV/DCV re-treatment that contributed to the L31V-Y93H double substitution after re-treatment.