Table 2. Characteristics of Placebo- and Antibiotic-Treated Cirrhotic and Control Rats.
| Indexes | Cirrhotic Rats |
Control Rats |
||
|---|---|---|---|---|
| Placebo (n = 10) | Antibiotics (n = 10) | Placebo (n = 8) | Antibiotics (n = 8) | |
| Total protein (g/dL) | 4.2 ± 0.8 | 5.0 ± 0.8 | 5.0 ± 0.4 | 5.2 ± 0.2 |
| Albumin (g/dL) | 1.9 ± 1.0 | 3.0 ± 0.3# | 3.3 ± 0.2* | 3.4 ± 0.2 |
| Globulin (g/dL) | 2.6 ± 0.6 | 2.4 ± 0.3 | 1.8 ± 0.1* | 1.8 ± 0.2** |
| Albumin/Globulin | 0.7 ± 0.3 | 1.3 ± 0.3# | 1.9 ± 0.1* | 1.9 ± 0.2** |
| ALT (U/L) | 204.5 ± 94.8 | 112.2 ± 24.6# | 44.0 ± 14.9* | 56.4 ± 10.2** |
| AST (U/L) | 546.3 ± 364.5 | 265.7 ± 56.9# | 70.7 ± 9.7* | 83.6 ± 9.0** |
| ALP (U/L) | 221.1 ± 132.3 | 109.5 ± 53.8 | 28.3 ± 36.8* | 30.0 ± 31.1** |
| GGT (U/L) | 24.2 ± 13.4 | 16.2 ± 8.6 | −2.7 + 1.6* | −3.2 + 1.1** |
| TBIL (μmol/L) | 39.3 ± 16.4 | 20.8 ± 10.7# | 2.0 ± 0.0* | 1.6 ± 0.9** |
| DBIL (μmol/L) | 33.7 ± 13.9 | 16.5 ± 7.1# | 2.0 ± 1.3* | 2.4 ± 0.9** |
| IBIL (μmol/L) | 5.2 ± 3.0 | 2.0 ± 2.6 | −0.3 + 1.5* | −0.8 + 1.1 |
| Initial body weight (g) | 217.2 ± 4.4 | 213.8 ± 7.3 | 214.2 ± 8.6 | 210.8 ± 8.0 |
| Final body weight (g) | 377.7 ± 48.5 | 390.0 ± 16.8 | 469.8 ± 10.2* | 469.2 ± 13.3** |
| Body weight increase (g) | 160.5 ± 45.7 | 176.2 ± 15.0 | 255.7 ± 11.4* | 258.3 ± 9.4** |
| Spleen weight (g) | 1.6 ± 0.3 | 1.3 ± 0.3# | 0.9 ± 0.1* | 0.9 ± 0.0** |
| Spleen weight/Final body weight (%) | 4.4 ± 1.0 | 3.2 ± 0.6# | 1.8 ± 0.1* | 1.9 ± 0.1** |
| Ascites amount (mL) | 24.3 ± 3.4 | 8.5 ± 2.3# | / | / |
| Ascites/Final body weight (mL/kg) | 64.6 ± 7.2 | 23.4 ± 6.0# | / | / |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, gamma-glutamyl transpeptidase; TBIL, total bilirubin; DBIL, direct bilirubin; IBIL, indirect bilirubin. The data are presented as the means ± standard deviation. *P < 0.05, placebo-treated normal rats versus placebo-treated cirrhotic rats; **P < 0.05, antibiotics-treated normal rats versus antibiotics-treated cirrhotic rats; #P < 0.05, antibiotics- versus placebo-treated cirrhotic rats. The unpaired Student’s t test with Bonferroni’s correction was used.