Table 1. Characteristics and Serum Lipid Levels in women according to OSA severity.
| No to mild OSA (n = 341) | Moderate OSA (n = 95) | Severe OSA (n = 134) | P | P for trend | |
|---|---|---|---|---|---|
| Characteristics | |||||
| Age (yrs) | 44(36–53) | 54(47–60) | 55(47–60) | <0.01 | <0.01 |
| BMI(kg/m2) | 23.6 ± 3.3 | 25.4 ± 3.3 | 28.2 ± 4.5 | <0.01 | <0.01 |
| NC (cm) | 34.0 ± 2.7 | 35.6 ± 2.6 | 37.4 ± 2.9 | <0.01 | <0.01 |
| WC (cm) | 83.8 ± 9.2 | 89.6 ± 8.5 | 96.0 ± 11.4 | <0.01 | <0.01 |
| HC (cm) | 95.0 ± 6.6 | 98.6 ± 6.2 | 102.5 ± 9.0 | <0.01 | <0.01 |
| WHR | 0.88 ± 0.07 | 0.91 ± 0.06 | 0.94 ± 0.06 | <0.01 | <0.01 |
| AHI | 2.2(0.5–7.0) | 22.0(19.3–25.3) | 56.0(39.1–74.1) | <0.01 | <0.01 |
| LSpO2 | 92.0(88.0–95.0) | 81.0(74.0–86.0) | 73.0(62.0–81.0) | <0.01 | <0.01 |
| ODI | 3.5(0.5–7.7) | 25.4(20.3–31.3) | 61.6(45.6–80.5) | <0.01 | <0.01 |
| MAI | 10.8(6.1–20.5) | 18.8(7.7–27.0) | 30.6(9.1–49.1) | <0.01 | <0.01 |
| Glucose | 4.9(4.6–5.3) | 5.4(5.0–6.0) | 5.5(5.0–6.1) | <0.01 | <0.01 |
| Insulin | 7.3(4.9–10.3) | 10.7(7.2–15.6) | 12.82(9.33–19.62) | <0.01 | <0.01 |
| HOMA-IR | 1.6(1.0–2.4) | 2.6(1.8–4.1) | 3.1(2.1–5.1) | <0.01 | <0.01 |
| Serum lipid levels | |||||
| TC | 4.60 ± 0.99 | 5.00 ± 0.91 | 4.98 ± 0.92 | 0.22 | 0.18 |
| TG | 1.00(0.70–1.49) | 1.40(0.99–1.96) | 1.56(1.08–2.22) | 0.07 | 0.21 |
| HDL-C | 1.26 ± 0.27 | 1.26 ± 0.28 | 1.19 ± 0.25 | 0.51 | 0.59 |
| LDL-C | 2.82 ± 0.88 | 3.12 ± 0.80 | 3.13 ± 0.81 | 0.30 | 0.20 |
| apoA-I | 1.18 ± 0.20 | 1.19 ± 0.19 | 1.16 ± 0.21 | 0.81 | 0.52 |
| apoB | 0.76 ± 0.18 | 0.84 ± 0.15 | 0.87 ± 0.16 | 0.09 | 0.04 |
| apoE | 4.18(3.39–5.02) | 4.66(3.98–5.31) | 4.68(3.70–5.85) | 0.60 | 0.54 |
| Lp(a) | 9.30(5.14–19.30) | 9.10(5.30–13.50) | 10.40(5.68–20.00) | 0.04 | 0.40 |
Abbreviations: OSA, obstructive sleep apnea; BMI, Body mass index; NC, neck circumference; WC, waist circumference, HC, hip circumference; WHR, waist to hip ratio; HOMA-IR, insulin resistance index calculated by the homeostasis model assessment; AHI, apnea-hypopnea index;LSpO2, lowest oxygen saturation; ODI, oxygen desaturation index; MAI, microarousal index;TC, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; apo, apolipoprotein; Lp(a), lipoprotein(a).
Differences of characteristics among three groups were examined by using ANOVA. Differences of serum lipid levels were examined by using ANCOVA, with P values adjusted for age, BMI, WHR, insulin and glucose. P for trend was tested using the polynomial linear trend test for continuous variables.