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. 2017 Jan 30;7:41738. doi: 10.1038/srep41738

Figure 6. RBM3 downregulates NO-induced miR-143 in p38-dependent way.

Figure 6

qPCR was performed to detect miR-143 expression for all the following samples. (A) SH-SY5Y cells were transfected with plasmid pXJ40-myc (Veh) or pXJ40-myc-RBM3 (RBM3) for 2 d, and treated with SNP (1 mM) for 16 h. (B) Cells were pre-cultured at 37 °C or 32 °C for 1 d and treated with SNP at 37 °C for 16 h. (C) 2 d post transfection of RBM3 siRNA or scramble siRNA (scr), cells were treated as shown in panel B. (D) In the presence of p38 inhibitor (SB, 10 μM), cells were treated with SNP for 16 h. Gray columns indicate cells without SNP treatment, and black ones indicate cells with SNP treatment. **P < 0.01 and ***P < 0.001 versus control group.