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. 2016 Nov 14;6(1):1–7. doi: 10.1242/bio.021519

Fig. 3.

Fig. 3.

Chromatin immunoprecipitation of REV-ERBα, HNF6, PPARα and PER2 on the Fgf21 promoter of liver chromatin. (A) Binding of REV-ERBα to its own promoter and to the Bmal1 and Fgf21 promoters at Zeitgeber time (ZT) 10 (black bars) and ZT22 (white bars), respectively. (B) Binding of HNF6 to the R1-R4 elements on the Fgf21 promoter at ZT10 and ZT22. (C) Binding of PPARα on the Bmal1 and Fgf21 promoters in the liver of wild-type (black bars) and Rev-erbα−/− (red bars) animals at ZT8 and ZT20. (D) Binding of PER2 on the Bmal1 and Fgf21 promoters in the liver of wild-type (black bars) and Rev-erbα−/− (red bars) animals at ZT8 and ZT20. All panels: two-way ANOVA with Bonferroni post-test, n=3, *P<0.05, ***P<0.001; values are means±s.e.m.