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Cellular metabolic defect associated with Trex1−/− is STING-dependent but IRF3-independent. (A) Serum levels of indicated inflammatory cytokines in WT, Trex1−/−, Trex1−/−Stinggt/gt, and Trex1−/−Irf3−/− mice. (B) Survival curve of Trex1−/−, Trex1−/−Stinggt/gt, and Trex1−/−Irf3−/− mice. (C) Real-time changes in the OCR of WT, Trex1−/−, Trex1−/−Stinggt/gt, and Trex1−/−Irf3−/− BMDMs. Data are representative of at least two independent experiments.
