Fig. 5.

Leptin deficiency (Ob/Ob) increases lipogenesis and survival of Trex1^−/− mice without dampening inflammation. (A) Body weights of mice of indicated genotypes on normal chow diet for 6 wk (n = 5–10). (B) Serum levels of indicated inflammatory cytokines. (C) Body weights of mice of indicated genotypes on normal chow diet for a period 17 wk (n = 5–10). (D) High-resolution micro-CT scan images of WT and Trex1^−/− mice on Ob/Ob background (front view of two separate mice, red indicates fat mass). (E) Survival curve of mice of indicated genotypes (n = 5–10). Data are presented as the means ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001. (A and B, Student’s t test; E, log-rank test.)