Fig. 6.
Trex1−/− mice support accelerated growth of implanted breast cancer cells. (A) E0771 breast tumor growth in WT and Trex1−/− mice; 5 × 105 E0771 cells were injected into mammary pads of female WT and Trex1−/− mice. Tumor sizes were recorded weekly (n = 9). (B) Representative images of primary and metastatic tumor at week 4 from WT or Trex1−/− mice. (C) E0771 breast tumor growth in WT and Trex1−/−Stinggt/gt and Trex1−/−Irf3−/− mice. E0771 cells were injected as in A. Data are presented as the means ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant (Student’s t test).