Fig. 3.

DCIR expression results in impaired bacterial clearance and controls pathology in M. tuberculosis-infected mice. (A–C) WT or KO mice were infected intranasally with ∼1,000 cfu of M. tuberculosis H37Rv. Lungs and spleen were collected after 21 or 42 d of infection and analyzed for colony-forming unit (CFU) content (A), cell infiltration (B), and immune cell subsets at 42 d (C). In A, each symbol represents colony-forming units from one animal. Data are representative of three independent experiments. In B and C, data are presented as means ± SEM of at least 25 fields chosen from at least 3 independent tissue slices and are representative of 2 independent experiments. Statistical analysis was performed using Student’s t test. *P < 0.05, **P < 0.01. (C, Top Left, Bottom Left, and Top Center) CD3⁺ T cells. (C, Bottom Center and Right) Quantification of other cell types (F4/80-expressing macrophages and B220-expressing B lymphocytes). Pictures are displayed in SI Appendix, Fig. S7A.