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AD-derived mutations in PS1. (A) A topology diagram of PS1. The residues, each mutated to only one type of amino acid, are colored red. The residues, each mutated to two or more types of amino acid, are colored yellow. (B) A flowchart on the selection of 138 PS1 mutations for in-depth analysis. These 138 mutations include 129 missense mutations, seven truncations, and two insertions. All 121 AD-targeted amino acids are covered by these 138 mutations.
