IFN induction in response to different RV strains. Independent samples of HIEs from six individuals (j2, j3, j6, j8, j10, and j11) were mock- or RV-inoculated (MOI of 10) with an animal strain (i.e., RRV) or one of two human strains (Wa and Ito), and transcriptional responses at 6 hpi were assessed by RT-qPCR. Data are of HIEs from six individuals and are a compilation of two independent experiments. Results are expressed as geometric mean ± 95% CI of the geometric mean (n = 6 biological replicates). Statistical analyses are shown for levels of IFNL1 using the Wilcoxon signed-rank test.