Fig. 5.

Liver and erythrocyte XOR nitrite reductase activity is enhanced in ApoE KO mice. Liver from ApoE KO mice exhibited greater nitrite reductase activity vs. WT at pH 7.4 (A) and pH 6.8 (B). The same pattern was observed in erythrocytes (G and H). Allopurinol had no effect on nitrite reductase activity from liver (C and D) or erythrocytes (I and J) from WT mice, in comparison ApoE KO mice exhibited reduced nitrite reductase activity in liver (E and F) and erythrocytes (K and L). Data are shown as mean ± SEM of n = 5. Statistical significance was determined using two-way ANOVA represented by ^#P < 0.05, ^##P < 0.01, or ^###P < 0.001, followed by Sidak’s multiple posttest represented by *P < 0.05, **P < 0.01, or ***P < 0.001, significantly different from WT or control.