Table 1.
Comparison of baseline levels of nitrite and nitrate in blood and tissue homogenates
| Tissue | Nitrite | Nitrate | ||||
| WT | ApoE KO | P value | WT | ApoE KO | P value | |
| Plasma (µmol/L) | 0.6 ± 0.1 (11) | 0.5 ± 0.1 (12) | 0.18 | 37.7 ± 2.3 (11) | 20.0 ± 2.8 (12) | <0.0001 |
| RBC (nmoles/g) | 0.4 ± 0.1 (5) | 0.3 ± 0.1 (5) | 0.26 | 13.1 ± 1.4 (5) | 6.3 ± 1.3 (5) | <0.01 |
| Aorta (nmoles/g) | 102.5 ± 7.3 (10) | 112.9 ± 10.1 (13) | 0.44 | 1014.4 ± 142.5 (10) | 503.7 ± 51.6 (13) | <0.01 |
| Kidney (nmoles/g) | 4.9 ± 0.7 (13) | 5.2 ± 0.7 (10) | 0.80 | 352.6 ± 36.9 (13) | 105.1 ± 13.8 (10) | <0.0001 |
| Lung (nmoles/g) | 12.6 ± 1.4 (11) | 17.4 ± 1.8 (11) | 0.05 | 349.1 ± 33.3 (11) | 148.4 ± 31.9 (11) | <0.001 |
| Heart (nmoles/g) | 4.7 ± 0.7 (11) | 3.3 ± 0.6 (11) | 0.12 | 204.9 ± 13.3 (11) | 126.9 ± 12.1 (11) | <0.001 |
| Liver (nmoles/g) | 5.0 ± 0.7 (13) | 4.4 ± 0.7 (12) | 0.50 | 130.7 ± 12.8 (13) | 80.3 ± 14.7 (12) | <0.05 |
| Mesentery (nmoles/g) | 29.2 ± 1.9 (11) | 56.0 ± 5.2 (8) | <0.0001 | 287.1 ± 37.2 (11) | 426.1 ± 61.11(8) | 0.056 |
Statistical comparison using unpaired t test between WT and ApoE KO littermate mice at 12 wk of age. Data are shown as mean ± SEM of (n) mice. Statistical significance determined using unpaired t test.