Table 1. Effect of SNc lesion on the expression of striatal DA receptors subtypes.
| Structure | Left side |
Right side |
||
|---|---|---|---|---|
| Sham | 6-OHDA | Sham | 6-OHDA | |
| D3R | ||||
| DLS | 7.3 (±0.5) | 2.06*** (±0.4) | 7.4 (±0.7) | 3.4** (±0.8) |
| DMS | 11.9 (±1) | 9.5 (±1.1) | 12.9 (±1.1) | 10.9 (±1.1) |
| N.Ac | 23.8 (±1.2) | 24.8 (±1.2) | 23.7 (±2) | 24.2 (±2.3) |
| D1R | ||||
| DLS | 36.6 (±3.6) | 29.5 (±2.6) | 36.5 (±3.4) | 30.1 (±2.6) |
| DMS | 38.4 (±3.7) | 32.7 (±2.7) | 38.4 (±3.4) | 33.7 (±2.8) |
| N.Ac | 37.1 (±3.7) | 32.6 (±2.6) | 37.6 (±3.2) | 33.8 (±2.6) |
| D2R | ||||
| DLS | 85.9 (±4.4) | 85.8 (±5.4) | 81 (±4.4) | 80.1 (±6.6) |
| DMS | 74.7 (±4.1) | 72.2 (±4.1) | 73.9 (±4.3) | 72.6 (±5.9) |
| N.Ac | 53.4 (±3.2) | 53.6 (±3.6) | 53.7 (±3.3) | 54.2 (±5.4) |
Modifications of expression of D3R, D1R, and D2R at striatal level induced by a bilateral 6-OHDA SNc lesion. Values of relative optical densities (arbitrary units) are expressed as a mean ± SEM. Two-way ANOVAs and post-hoc analyses with the method of contrasts were used.
**p < 0.01, ***p < 0.001, sham (n = 8) vs 6-OHDA (n = 7). DLS: dorsolateral striatum; DMS: dorsomedial striatum; NAc: nucleus accumbens.