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. 2017 Jan 30;7:41565. doi: 10.1038/srep41565

Table 4. Comparison of the ROC curve, IDI and NRI of the modified CHA₂DS₂-VASc vs. original CHA₂DS₂-VASc in predicting endpoints.

	C-index	95% CI p	p^*	IDI	p	NRI	p
(A) Composite cardiovascular end-point
CHA₂DS₂-VASc	0.630	0.603–0.658 < 0.001	0.111	0.0065	<0.001	−0.016	0.012
CHA₂DS₂-VASc+vWF	0.641	0.613–0.668 < 0.001	0.111	0.0065	<0.001	−0.016	0.012
(B) Stroke
CHA₂DS₂-VASc	0.610	0.582–0.637 p < 0.001	0.131	0.0037	0.040	−0.017	<0.001
CHA₂DS₂-VASc+vWF	0.623	0.595–0.650 p < 0.001	0.131	0.0037	0.040	−0.017	<0.001
(C) All-cause mortality
CHA₂DS₂-VASc	0.661	0.634–0.688 p < 0.001	0.076	0.0091	0.048	0.001	0.864
CHA₂DS₂-VASc+vWF	0.670	0.643–0.697 p < 0.001	0.076	0.0091	0.048	0.001	0.864
(D) Cardiovascular mortality
CHA₂DS₂-VASc	0.656	0.628–0.683 p < 0.001	0.156	0.0041	0.033	−0.018	0.004
CHA₂DS₂-VASc+vWF	0.670	0.643–0.697 p < 0.001	0.156	0.0041	0.033	−0.018	0.004

CI = confidence interval; IDI = integrated discriminatory improvement; NRI = net reclassification improvement.

^*For c-index comparison.