Table II.
Generalized estimating equations (GEE) analysis of the relationship between expression levels of various DNA repair genes and breast cancer risk among sisters discordant for breast cancer in the Breast Cancer Family Registry (BCFRa).
| OR (95% CI) | Adjusted OR (95% CI) | |
|---|---|---|
| ATM (n=172 sets) | ||
| Continuous | 1.10 (1.02,1.18) | 1.10 (1.02, 1.18) |
| T3 (>1.34) | 1.00 (referent) | 1.00 (referent) |
| T2 (>0.57−≤1.34) | 1.03 (0.66,1.61) | 1.02 (0.66, 1.59) |
| T1 (≤0.57) | 1.33 (0.90,1.96) | 1.35 (0.92, 1.99) |
| BRCA1 (n=114 sets) | ||
| Continuous | 1.43 (0.13, 16.04) | 1.52 (0.14, 16.93) |
| T3 (>0.05) | 1.00 (referent) | 1.00 (referent) |
| T2 (>0.02−≤0.05) | 1.21 (0.73, 2.03) | 1.23 (0.73, 2.06) |
| T1 (≤0.02) | 0.74 (0.43, 1.26) | 0.75 (0.44, 1.27) |
| MSH2 (n=155 sets) | ||
| Continuous | 2.09 (0.48, 9.03) | 2.17 (0.51, 9.24) |
| T3 (>0.09) | 1.00 (referent) | 1.00 (referent) |
| T2 (>0.03−≤0.09) | 0.93 (0.56, 1.53) | 0.92 (0.55, 1.54) |
| T1 (≤0.03) | 1.87 (1.19, 2.92) | 1.90 (1.21, 2.97) |
| MUTYH (n=134 sets) | ||
| Continuous | 0.99 (0.89, 1.09) | 0.99 (0.90, 1.09) |
| T3 (>1.02) | 1.00 (referent) | 1.00 (referent) |
| T2 (>0.39−≤1.02) | 0.96 (0.58, 1.59) | 0.97 (0.59, 1.59) |
| T1 (≤0.39) | 1.02 (0.69, 1.51) | 1.02 (0.68, 1.51) |
| XPC (n=178 sets) | ||
| Continuous | 1.01 (0.98, 1.03) | 1.01 (0.98, 1.03) |
| T3 (>3.30) | 1.00 (referent) | 1.00 (referent) |
| T2 (>1.05−≤3.30) | 0.90 (0.59, 1.38) | 0.90 (0.58, 1.38) |
| T1 (≤1.05) | 1.18 (0.81, 1.73) | 1.18 (0.81, 1.74) |
a
Model adjusted for age at blood draw and smoking status; OR, odds ratio; CI, confidence interval.