Table 5. MR analysis for the association of triglyceride with FI based on a cross-sectional design in the ageing arm (n = 1750)^†.

Model※	rs662799 (Per C allele)			MR analysis
	β‡	95% CI	P Value	β‡	95% CI	P Value
1	0.003	−0.004, 0.009	0.442	0.008	−0.013, 0.029	0.440
2	0.002	−0.004, 0.008	0.551	0.006	−0.014, 0.026	0.550
3	0.003	−0.004, 0.009	0.426	0.008	−0.011, 0.027	0.425
4	0.002	−0.005, 0.008	0.559	0.006	−0.016, 0.028	0.579

MR, Mendelian randomization; CI, confidence interval; FI, frailty index. ^†The numbers vary because of missing data in variables. ^※Model 1 unadjusted model; model 2 adjusted for age and sex; model 3 additionally adjusted for education level, marital status, smoking and drinking habit, body mass index, systolic blood pressure, and diastolic blood pressure; model 4 used bootstrapping with 1000 replications for internal validation for model 2. ^‡β refers to the average change in FI (no unit) with each additional copy of C allele of this variant rs662799 or each unit (mmol/L) increase in genetically predicted triglycerides.