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. 2017 Jan 30;18:21. doi: 10.1186/s13059-016-1146-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Validation of Chrom3D structures by FISH. a Expected radial distribution of ten FISH probes designed to the nucleus center (3 c probes), intermediate (4 i probes), and peripheral (3 p probes) areas, across 400 structures; *P < 2.2 × 10^–16 (Mann–Whitney U tests). b Observed radial distribution of 1105 FISH signals for the ten probes analyzed in (a); *P < 10^–4; ns, non-significant (Mann–Whitney U tests). Quantitative data for each individual probe are shown in Additional file 1: Figure S9b, c. c Correlation between observed and expected relative distance of FISH signals to the NP. d Examples of FISH images for each radial category (planar and orthogonal views); periphery, probe p1; center, probe c3; intermediate, probe i1. Bar, 5 μm