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. 2017 Jan 1;144(1):17–32. doi: 10.1242/dev.133058

Fig. 1.

Fig. 1.

The growth of single cell genome-wide profiling techniques. A surge in scRNA-Seq applications can be observed. The cumulative number of cells that have been subjected to scRNA-Seq is shown, separated by species. Landmark studies are highlighted. Tang et al. (2009), Tang (2010b), Islam (2011), Ramskold (2012) and Hashimshony (2012) are the first five scRNA-Seq studies. They introduced the major varieties of scRNA-Seq: Tang protocol, STRT-Seq, CEL-Seq and Smart-Seq. Yan (2013) and Xue (2013) leverage scRNA-Seq to explore and the dynamics of human zygotic genome activation. Picelli (2013) introduces Smart-Seq2 with increased sensitivity. Macosko (2015) and Klein (2015) introduce high-throughput low-cost droplet-based methods that have vastly increased the number of cells that can be sequenced.