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. 2017 Jan 1;144(1):63–73. doi: 10.1242/dev.138545

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Expression of mitochondrial ETC genes increases from E8.5 to E9.5. (A) Heatmap representation of mitochondrial electron transport chain (ETC)-related genes that were differentially expressed between E8.5 and E9.5 in a microarray analysis. n=3 independent sample replicates. Fold change ≥1.5 versus E8.5. P<0.05 versus E8.5 (one-way ANOVA with Tukey's post-hoc test). Multiple testing correction, Benjamini–Hochberg FDR; hierarchical clustering with Manhattan distance. E8.5, ss 10-12; E9.5, ss 24-25; E10.5, ss 35-37. Components of each complex were picked up by referring to gene ontology terms. (B) Quantification of the mitochondrial DNA (mtDNA)/nuclear DNA (nDNA) ratio by qPCR. No statistically significant difference (n.s.; two-tailed Welch's t-test) was observed between E8.5 (ss 10-12) and E9.5 (ss 23-24); n=7 and n=4 independent sample replicates. Data are represented as mean±s.d.