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. Author manuscript; available in PMC: 2018 Feb 3.
Published in final edited form as: Neurosci Lett. 2016 Dec 21;639:103–113. doi: 10.1016/j.neulet.2016.12.049

Figure 1. Transport activities of P-gp, BCRP and MRP2 in brain and spinal cord capillaries of SOD rats at ALS pre-onset, symptomatic onset or symptomatic stage and age-matched wildtype rats.

Figure 1

Figure 1

Figure 1

Representative confocal images showing luminal accumulation of (A) NBD-CSA, (B) Bodipy-prazosin and (C) Texas Red in brain and spinal cord capillaries. At least 10 capillaries from at least two capillary preparations (pooled tissue from at least four rats) were analyzed from each ALS stage of SOD and age-matched wildtype rats. Percent change (normalized to agematched wildtypes) of specific transport activity are presented with S.E.M.. Scale bars in confocal images indicates 10 µm. One-way ANOVA with Dunnett’s multiple comparisons post-hoc test was performed. Post-hoc test with p <0.05 was considered a significant difference compared to capillaries of SOD rats at pre-onset stage.