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A and B, OVA-specific IgE (Fig 7, A) and IgG2a (Fig 7, B) production in mice epicutaneously (EC) treated with OVA and CpG after EC immunization with OVA alone. C and D, OVA-specific IgE (Fig 7, C) and IgG2a (Fig 7, D) secretion in recipients injected with regulatory ALNCs before immunization or before challenge with OVA. Fig 7, A and B, n = 6–8; Fig 7, C and D, n = 4–5. ns, Not significant. *P < .05, **P < .01, and ***P < .001.
