TABLE 2.
Population pharmacokinetic parameters of caspofungin (n = 20)
| Parametera | Median (range) |
|---|---|
| AUC0–24 (mg · h/liter) | 78.1 (61.4–129.4) |
| Cmin (mg/liter) | 1.7 (1.1–3.9) |
| Cmax (mg/liter) | 7.4 (4.7–14.7) |
| CL (liters/h) | 0.66 (0.37–1.26) |
| V1 (liters) | 9.1 (5.5–13.2) |
| V2 (liters) | 8.6 (5.2–59.0) |
| t1/2α (h) | 2.5 (2.2–4.0) |
| t1/2β (h) | 19.8 (12.3–66.0) |
a
Abbreviations: AUC0–24, area under the concentration-time curve from 0 to 24 h; Cmax, maximal concentration; Cmin, minimal concentration; CL, clearance; V1, volume of distribution in the central compartment; V2, volume of distribution in the peripheral compartment; t1/2α, half-life at α phase; t1/2β, half-life at β phase.