TABLE 4.
Spearman correlations with the caspofungin AUC0–24a
| Characteristic | Correlation coefficient | P value |
|---|---|---|
| Age (years) | 0.093 | 0.698 |
| Caspofungin dose (mg/kg/day) | 0.057 | 0.011 |
| Liver enzymes | ||
| ALT (U/liter) | −0.267 | 0.255 |
| AST (U/liter) | −0.259 | 0.270 |
| Bilirubin (μmol/liter) | −0.109 | 0.657 |
| Alkaline phosphatase (U/liter) | −0.085 | 0.729 |
| γ-Glutamyl transpeptidase (U/liter) | −0.060 | 0.801 |
| Albumin (g/liter) | 0.213 | 0.367 |
| Disease severity scores | ||
| APACHE II | 0.220 | 0.352 |
| APACHE IV | 0.194 | 0.426 |
| SAPS3 | 0.341 | 0.141 |
| SOFA | 0.216 | 0.361 |
a
Abbreviations: AUC0–24, area under the concentration-time curve from 0 to 24 h; ALT, alanine aminotransaminase; APACHE, acute physiology and chronic health evaluation; AST, aspartate aminotransaminase; SAPS, simplified acute physiology score; SOFA, sepsis-related organ failure assessment.