TABLE 2.
Values of LPV and 3TC pharmacokinetic parametersa
| Treatment and parameter | Median (IQR) value atb: |
||
|---|---|---|---|
| Wk 6 | Wk 26 | Wk 38 | |
| LPV | |||
| Dose BID (mg) | 40 (40–40) | 80 (80–80) | 80 (80–80) |
| CL/F per kg (liter/h/kg) | 0.17 (0.12–0.29) | 0.09 (0.08–0.20) | 0.16 (0.08–0.22) |
| Ctrough (mg/liter) | 2.83 (1.73–4.43) | 5.57 (3.17–7.68) | 3.39 (2.28–7.26) |
| Cmax (mg/liter) | 5.82 (3.63–9.01) | 10.52 (6.33–14.75) | 6.49 (4.29 −12.86) |
| Tmax (h) | 3.0 (3.0–3.0) | 3.0 (3.0–3.1) | 3.1 (3.0–3.1) |
| AUC0–12 (mg · h/liter) | 54.5 (33.9–85.8) | 101.4 (60.3–141.4) | 62.1 (41.0–126.5) |
| 3TC | |||
| Dose BID (mg) | 7.5 (7.5–7.5) | 25 (25–25) | 50 (25–50) |
| CL/F per kg (liter/h/kg) | 0.32 (0.24–0.43) | 0.61 (0.53–0.76) | 0.70 (0.49–0.79) |
| Ctrough (mg/liter) | 0.15 (0.12–0.24) | 0.11 (0.09–0.16) | 0.13 (0.09–0.17) |
| Cmax (mg/liter) | 0.89 (0.66–1.19) | 1.10 (0.94–1.49) | 1.45 (0.97–1.68) |
| Tmax (h) | 2.0 (1.7–2.3) | 1.7 (1.4–2.0) | 1.6 (1.4–1.9) |
| AUC0–12 (mg · h/liter) | 5.6 (4.1–7.8) | 5.9 (5.1–7.5) | 7.3 (4.9–8.5) |
a
Abbreviations: LPV, lopinavir; 3TC, lamivudine; IQR, interquartile range; BID, twice daily; CL/F, apparent clearance; Ctrough, trough concentration, Cmax, maximal concentration, Tmax, time to reach the maximal concentration; AUC0–12, area under the curve from 0 to 12 h after the last drug intake.
b
For treatment with LPV, data are for 44, 26, and 14 infants at weeks 6, 26, and 38, respectively. For treatment with 3TC, data are for 77, 49, and 34 infants at weeks 6, 26, and 38, respectively.