TABLE 4.

Results for samples with 3TC AUC_0–12 values of ≥4.2 mg · h/liter for the different population analysis sets

Wt band (kg)	Overall population		ANRS 12174 protocol dose populationa		WHO simulated populationa,b
	n obs.c	No. (%) of infants with an AUC0–12 of ≥4.2 mg · h/liter	n obs.	No. (%) of infants with an AUC0–12 of ≥4.2 mg · h/liter	n obs.	No. (%) of infants with an AUC0–12 of ≥4.2 mg · h/liter
<4	15	9 (60)	13	9 (69)	13	12 (92)
≥4–8	117	82 (70)	107	97 (91)	107	103 (96)
≥8	48	36 (75)	40	36 (90)	40	35 (88)

^aData for samples from infants that may have missed a dose at the sampling time were excluded.

^bData for the WHO simulated population are simulated concentrations that the 2016 WHO dosing guidelines would produce for HIV-1-infected children.

^cn obs., number of observations.