TABLE 1.
Participant characteristics
| Characteristica | Value for: |
|
|---|---|---|
| RG7667 (n = 60) | Placebo (n = 60) | |
| Age (yr), mean (SD) | 49.2 (14.3) | 49.5 (12.9) |
| Male sex | 42 (70.0) | 42 (70.0) |
| Race | ||
| White | 49 (81.7) | 49 (81.7) |
| Ethnicity | ||
| Not Hispanic or Latino | 53 (88.3) | 49 (81.7) |
| Height (cm), mean (SD) | 173.1 (12.0) | 173.5 (10.5) |
| Weight (kg), mean (SD) | 80.0 (16.0) | 81.8 (16.2) |
| Reason for transplantation | ||
| Diabetes and/or hypertension | 20 (33.3) | 18 (30.0) |
| Glomerulonephritis | 17 (28.5) | 12 (20.0) |
| Polycystic kidney disease | 8 (13.3) | 13 (21.7) |
| Other/unknown/not specified | 15 (25.4) | 17 (28.3%) |
| Region: United States | 29 (48.3) | 29 (48.3) |
| ATGb and/or alemtuzumab for induction of immunosuppression | 14 (23.3) | 16 (26.7) |
| Donor type | ||
| Deceased | 35 (58.3) | 36 (60.0) |
| Living, related | 16 (26.7) | 13 (21.7) |
| Living, unrelated | 9 (15.0) | 9 (15.0) |
| Missing | 0 | 2 (3.3) |
| HLA-A mismatchc | ||
| 0 | 18 (30.0) | 16 (26.7) |
| 1 | 28 (46.7) | 25 (41.7) |
| 2 | 10 (16.7) | 13 (21.7) |
| Not done or unobtainable | 4 (6.7) | 6 (10.0) |
| HLA-B mismatch | ||
| 0 | 16 (26.7) | 19 (31.7) |
| 1 | 21 (35.0) | 17 (28.3) |
| 2 | 19 (31.7) | 17 (28.3) |
| Not done or unobtainable | 4 (6.7) | 7 (11.7) |
| HLA-DR mismatch | ||
| 0 | 17 (28.3) | 16 (26.7) |
| 1 | 20 (33.3) | 28 (46.7) |
| 2 | 16 (26.7) | 9 (15.0) |
| Not done or unobtainable | 7 (11.7) | 7 (11.7) |
a
Data are numbers (percent) unless otherwise specified.
b
ATG, antithymocyte globulin.
c
HLA, human leukocyte antigen.