Table 4.
Selected genes constitutively expressed by RCC and melanoma metastases.
| UNIQID | NAME | Extended Name | Median log2Cy5/Cy3 | Averagelog2Cy5/Cy3 | t-test* | ||||
| RCC | MEL | OTH | RCC | MEL | OTH | p2-value | |||
| 274276 | IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.74 | 0.30 | -0.28 | 0.54 | 0.18 | -0.23 | 0.06 |
| 191173 | ITGB7 | integrin, beta 7 | 0.17 | 0.33 | -0.26 | 0.14 | 0.30 | -0.26 | 0.51 |
| 191169 | FLT3LG | fms-related tyrosine kinase 3 ligand | 0.18 | 0.32 | -0.27 | 0.31 | 0.19 | -0.20 | 0.53 |
| 187264 | CORO1A | coronin-like protein p57=actin binding protein p57 | 0.38 | 0.13 | -0.19 | 0.47 | 0.12 | -0.17 | 0.16 |
| 189684 | SP110 | SP110 nuclear body protein | 0.22 | 0.60 | -0.56 | 0.26 | 0.44 | -0.42 | 0.27 |
| 279561 | TNFRSF7 | CD27 | -0.06 | 0.65 | -0.39 | -0.09 | 0.45 | -0.35 | 0.07 |
| 279871 | CD37 | CD37 antigen | 0.09 | 0.56 | -0.56 | 0.33 | 0.47 | -0.38 | 0.72 |
| 276143 | TAP2 | transporter 2 | 0.23 | 0.33 | -0.21 | 0.27 | 0.31 | -0.24 | 0.86 |
| 281103 | sialic acid binding Ig-like lectin 7=D-siglec=expressed in dendritic cells | 0.33 | 0.26 | -0.34 | 0.27 | 0.24 | -0.24 | 0.86 | |
| 279699 | BTK | btk = Bruton agammaglobulinemia tyrosine kinase || | -0.04 | 0.45 | -0.28 | -0.09 | 0.34 | -0.26 | 0.05 |
| 274604 | CST7 | cystatin F (leukocystatin) || | -0.14 | 0.37 | -0.29 | -0.07 | 0.45 | -0.34 | 0.06 |
| 281440 | ITGB7 | CD103 beta=Integrin beta 7 || | 0.36 | 0.39 | -0.25 | 0.31 | 0.38 | -0.35 | 0.67 |
| 191157 | KLRG1 | killer cell lectin-like receptor subfamily G, member 1 || | 0.32 | 0.40 | -0.17 | 0.35 | 0.23 | -0.25 | 0.39 |
| 274016 | RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) || | 0.48 | 0.38 | -0.29 | 0.36 | 0.30 | -0.29 | 0.78 |
| 274444 | ITGAL | integrin, alpha L (antigen CD11A (p180)| | 0.34 | 0.57 | -0.43 | 0.30 | 0.33 | -0.31 | 0.88 |
| 282504 | CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.84 | 0.66 | -0.53 | 0.62 | 0.51 | -0.50 | 0.76 |
| 274267 | KLRK1 | killer cell lectin-like receptor subfamily K, member 1 | 0.80 | 0.33 | -0.20 | 0.71 | 0.34 | -0.38 | 0.14 |
| 187290 | LILRB1 | LIR-7=PIR homologue| | 0.11 | 0.67 | -0.15 | 0.12 | 0.49 | -0.41 | 0.20 |
| 186380 | SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.14 | 0.34 | -0.21 | 0.34 | 0.36 | -0.34 | 0.94 |
| 188111 | CD3Z | CD3Z antigen, zeta polypeptide (TiT3 complex) | 0.09 | 0.42 | -0.30 | -0.01 | 0.35 | -0.27 | 0.10 |
| 186528 | SLA | SLAP=src-like adapter protein | 0.38 | 0.31 | -0.24 | 0.32 | 0.33 | -0.31 | 0.98 |
| 185279 | ASGR2 | asialoglycoprotein receptor 2| | 0.28 | 0.61 | -0.33 | 0.17 | 0.45 | -0.40 | 0.16 |
| 187450 | LILRB2 | leukocyte immunoglobulin-like receptor, subfamily B, member 2 | 0.10 | 0.65 | -0.45 | 0.13 | 0.54 | -0.44 | 0.07 |
| 184382 | FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog| | 0.57 | 0.23 | -0.29 | 0.40 | 0.27 | -0.28 | 0.49 |
| 190623 | MYO1F | myosin IF| | 0.18 | 0.50 | -0.22 | 0.16 | 0.46 | -0.38 | 0.24 |
| 188800 | PILRA | paired immunoglobin-like type 2 receptor alpha | 0.16 | 0.56 | -0.08 | 0.07 | 0.31 | -0.27 | 0.17 |
| 188004 | CLC | Charcot-Leyden crystal protein| | 0.08 | 0.51 | -0.33 | 0.08 | 0.53 | -0.44 | 0.08 |
| 186399 | PPP3CC | protein phosphatase 3, catalytic subunit, gamma isoform (calcineurin A gamma)| | 0.07 | 0.36 | -0.15 | 0.05 | 0.21 | -0.18 | 0.17 |
| 278997 | XLHSRF-1 | heat shock regulated 1 | -0.12 | 0.32 | -0.09 | 0.10 | 0.28 | -0.20 | 0.33 |
| 281827 | LLT1 | lectin-like NK cell receptor | 0.46 | 0.26 | -0.33 | 0.53 | 0.22 | -0.26 | 0.08 |
| 282466 | LLT1 | lectin-like NK cell receptor | 0.22 | 0.38 | -0.23 | 0.23 | 0.32 | -0.32 | 0.66 |
| 189527 | FMNL1 | formin-like 1 | 0.46 | 0.43 | -0.25 | 0.44 | 0.24 | -0.26 | 0.32 |
| 282550 | natural killer cell transcript 4 | -0.20 | 0.41 | -0.29 | 0.00 | 0.30 | -0.24 | 0.15 | |
| 282534 | B-cell CLL/lymphoma 2 | 0.05 | 0.38 | -0.38 | -0.05 | 0.33 | -0.34 | 0.05 | |
| 282477 | ICOS | inducible T-cell co-stimulator| | -0.07 | 0.37 | -0.18 | -0.07 | 0.28 | -0.26 | 0.07 |
| 282624 | granzyme A | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)| | -0.10 | 0.58 | -0.33 | -0.16 | 0.43 | -0.31 | 0.06 |
* Two-tailed un-paired t test between RCC and MEL samples. RCC = Renal cell carcinoma; Mel = melanoma lesions; Oth = all other tumors in the study (see Table I).