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Very high caspofungin concentrations exert additional antifungal activity beyond inhibition of the β-1,3-glucan synthase. Conidia of the indicated strains were inoculated in AMM in a 24-well plate (5 × 103 conidia per well). The medium was supplemented with the indicated amounts of CS. Representative dark-field images were taken after 3 and 5 days of incubation at 37°C.
