TABLE 1.
Baseline characteristics of children with TB with and without HIV coinfection
| Characteristic | Value for group |
P value | ||
|---|---|---|---|---|
| All (n = 113) | TB (n = 54) | TB/HIV (n = 59) | ||
| Median (IQR) age, yr | 5.0 (2.2–8.3) | 4.8 (2.0–8.3) | 5.0 (2.9–8.9) | 0.642 |
| No. (%) with age, yr | 0.822 | |||
| <2 | 24 (21.2) | 12 (22.2) | 12 (20.3) | |
| ≥2 | 89 (78.8) | 42 (77.8) | 47 (79.7) | |
| No. (%) with age, yr | 0.708 | |||
| <5 | 54 (47.8) | 27 (50.0) | 27 (45.8) | |
| ≥5 | 59 (52.2) | 27 (50.0) | 32 (54.2) | |
| No. (%) male | 63 (55.8) | 32 (59.3) | 31 (52.5) | 0.570 |
| Median (IQR) body wt, kg | 14.0 (8.8–19.5) | 14.1 (8.8–21.8) | 14.0 (8.5–19.0) | 0.406 |
| Median (IQR) height, cm | 99.0 (82.0–119.0) | 99.0 (82.0–122.0) | 98.0 (82.0–117.0) | 0.553 |
| Nutritional status | ||||
| Median (IQR) wt-for-age Z scorea | −2.5 (−3.8 to −1.4) | −2.1 (−3.1 to −0.9) | −2.7 (−4.0 to −2.0) | 0.023 |
| Median (IQR) height-for-age Z score | −2.0 (−3.2 to −1.1) | −1.6 (−2.4 to −0.6) | −2.8 (−3.9 to −1.8) | <0.001 |
| Median (IQR) BMI-for-age Z score | −1.8 (−2.9 to −0.5) | −1.4 (−2.9 to −0.6) | −2.0 (−3.4 to −0.4) | 0.547 |
| Median (IQR) midarm circumference, cm | 14.0 (12.0–16.0) | 14 (13.0–16.5) | 13 (11.2–15.5) | 0.131 |
| Median (IQR) head circumference, cm | 48.0 (46.0–50.0) | 48.0 (46.0–51.0) | 48 (45.0–49.0) | 0.143 |
| Median (IQR) drug dose, mg/kg | ||||
| Isoniazid | 11.2 (9.1–12.8) | 11.4 (9.5–12.8) | 10.4 (9.0–12.9) | 0.314 |
| Rifampin | 15.8 (13.6–18.8) | 16.7 (14.2–18.8) | 15.2 (13.5–18.8) | 0.262 |
| Pyrazinamide | 24.8 (22.6–30.0) | 26.5 (23.5–32.3) | 24.7 (22.3–29.0) | 0.228 |
| Ethambutol | 16.9 (15.0–20.6) | 18.0 (15.8–22.7) | 16.5 (14.9–19.4) | 0.167 |
| No. (%) with TB disease classification: | <0.001 | |||
| Pulmonary | 85 (75.2) | 29 (52.8) | 56 (94.9) | |
| Extrapulmonary | 28 (24.8) | 25 (47.2) | 3 (5.1) | |
| No. (%) with outcome: | 0.513 | |||
| Completed treatment | 99 (87.6) | 47 (85.2) | 52 (88.1) | |
| Lost to follow-up | 8 (7.1) | 4 (7.4) | 4 (6.8) | |
| Discontinued study | 4 (3.5) | 3 (5.6) | 1 (1.7) | |
| Died | 2 (1.8) | 0 (0.0) | 2 (3.4) | |
a
The software could not calculate weight-for-age Z score for participants who were over 10 years old.