TABLE 1.
Cross-resistance to dapivirine of plasma-derived viruses from individuals on failing first-line NNRTI-based ART
| Resistance category | No. (%) of samples (n = 100) | Median (range) |
||
|---|---|---|---|---|
| Standard IC50 (ng/ml) | Adjusted IC90 (ng/ml)a | Fold changeb | ||
| >500-fold | 25 (25) | ≥132 | ≥1,000 | ≥505 |
| 3- to 500-fold | 66 (66) | 17.6 (0.915–79.8) | 134 (6.95–606) | 67.4 (3.51–306) |
| <3-fold | 9 (9) | 0.383 (0.228–0.636) | 2.91 (1.74–4.83) | 1.47 (0.876–2.44) |
a
The DPV IC90 was calculated from the IC50 and adjusted for human serum protein binding using a factor of 3.8× as described in Materials and Methods.
b
Calculated using the IC50 values from 13 wild-type, plasma-derived subtype C HIV-1 viruses from South Africa as the denominator.