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. 2017 Jan 24;61(2):e01745-16. doi: 10.1128/AAC.01745-16

FIG 2.

FIG 2

Time-kill curve demonstrating synergistic killing of DAP plus beta-lactamase inhibitors. (A) Kill curve of static sub-MICs of DAP plus TAZ against MRSA strain Sanger 252 (black down triangles, growth control; black circles, DAP 2 mg/liter; black squares, TAZ 20 mg/liter; black up triangles, DAP 2 mg/liter plus TAZ 20 mg/liter); (B) Kill curve of static sub-MIC of DAP plus SLB against MRSA strain Sanger 252 (black down triangles, growth control; black circles, DAP 2 mg/liter; black squares, SLB 20 mg/liter; black up triangles, DAP 2 mg/liter plus SLB 20 mg/liter); (C) Simulated in vitro PK/PD modeling of DAP plus TAZ against daptomycin-nonsusceptible VISA D712 (dashed line, growth control; black circles, DAP 6 mg/kg/day; black squares, TAZ 500 mg q8h; black up triangles, DAP 6 mg/kg/day plus TAZ 500 mg q8h).