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Effect of combination passage with daptomycin in vitro on selection of daptomycin-nonsusceptible MRSA
| Drug exposure | Day 28 DAP MIC (mg/liter) |
|||||
|---|---|---|---|---|---|---|
| Replicate 1 | Replicate 2 | Replicate 3 | Replicate 5 | Replicate 5 | Median | |
| DAP | 8 | 12 | 24 | 32 | 32 | 24 |
| DAP + tazobactam | 1 | 16 | 16 | 16 | 32 | 16 |
| DAP + sulbactam | 8 | 32 | 32 | 32 | 64 | 32 |
| DAP + oxacillin | 0.02 | 0.05 | 1 | 3 | 3 | 1 |
