. Author manuscript; available in PMC: 2017 Jan 30.

Published in final edited form as: Ultrasound Obstet Gynecol. 2014 Jul;44(1):50–57. doi: 10.1002/uog.13287

Table 1.

Baseline estimates, obtained from the literature, of test characteristics for different screening approaches and of incidence of congenital heart disease (CHD): input values for the decision-analysis model

Variable/Reference	Baseline estimate
Variable/Reference	Sensitivity (range)	Specificity (range)
4C view^43–48	0.492 (0.210–0.810)	0.990 (0.988–0.999)
4C + outflow views^{28,29,45,48–50}	0.67 (0.31–0.86)	0.990 (0.970–0.999)
4C + outflow views by MFM^{16,30,51–53}	0.77 (0.55–1.00)	0.99 (0.97–1.00)
First-trimester NT^18,54	0.246 (0.080–0.560)	0.982 (0.965–0.992)
MFM referral ultrasound^16,52,55	0.80 (0.60–1.00)	0.982 (0.924–0.999)
Pediatric cardiology fetal echo- cardiogram^3,12,55	0.940 (0.900–0.976)	0.995 (0.993–1.000)
–Incidence of CHD^40–42	0.0075 (0.003–0.011)

4C, four chamber; MFM, maternal–fetal medicine specialist; NT, nuchal translucency.