Figure 3.
Change from baseline central subfield thickness (CST) after subretinal injection of RetinoStat. Subjects had measurement of CST by optical coherence tomography at baseline and at 1, 2, 4, 8, 12, 16, 20, 24, and 48 weeks after subretinal injection of 2.4 × 104 TU (A, cohort 1), 2.4 × 105 TU (B, cohort 2), or 8.0 × 105 TU (C, cohort 3; D and E, cohort 4) of RetinoStat. Subjects in cohort 4 are divided into those that did not receive any anti-VEGF injections (D) and those that received at least one anti-VEGF injection (E). There was little mean change (±standard deviation [SD]) in CST between baseline and week 48 in the 15 patients in cohorts 3 and 4 who had a subretinal injection of 8.0 × 105 TU of RetinoStat (F).