Fig 5. Writers and erasers of histone-acetylation (Ac) and protein-ubiquitination (Ubq) in budding yeast share features with kinases and phosphatases.
A. Writer-coding genes are more abundant than eraser-coding genes. B. Writer proteins are significantly less abundant than all proteins (Ac p = 3.7*10−3, Ubq p = 1.4*10−5; Mann-Whitney test). C. Few eraser genes in budding yeast are essential (0% in acetylation, and 9.5% in the ubiquitination systems), in contrast to more than 21% of the writers (Ac p = 0.035; Fisher exact test). D. Acetylation writers, ubiquitination writers and ubiquitination erasers are significantly more connected by PPIs relative to all proteins (p = 0.0018, p = 0.0035 and p = 0.042, respectively, Mann-Whitney test). Box plots show the values at the first, second and third quartiles. ++ indicate p<10−3; */+ indicates p<0.05. In parenthesis are the numbers of writers and erasers for which data were available. Numbers above bars indicate Y-axis values.