Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2017 Jan 30.

Published in final edited form as: Biomaterials. 2011 Mar 23;32(19):4464–4470. doi: 10.1016/j.biomaterials.2011.02.048

Fig 1 — Effect of drug loading on the localization of anti-inflammatory properties. (A) Injection pattern showing administration sites of PLGA particles without ( ) and with ( ) dexamethasone. (B) Near-infrared fluorescent imaging showed a high level of cathepsins at the injection sites of control particles but localized inhibition of these enzymes at the sites of particles with low drug loading. (C) Inhibition of cathepsin activity at all injection sites was observed when particles with high drug loading were investigated. (D) In vitro release profiles of dexamethasone showed a more pronounced initial burst release from microparticles with high drug loading.

Inline graphic — Effect of drug loading on the localization of anti-inflammatory properties. (A) Injection pattern showing administration sites of PLGA particles without ( ) and with ( ) dexamethasone. (B) Near-infrared fluorescent imaging showed a high level of cathepsins at the injection sites of control particles but localized inhibition of these enzymes at the sites of particles with low drug loading. (C) Inhibition of cathepsin activity at all injection sites was observed when particles with high drug loading were investigated. (D) In vitro release profiles of dexamethasone showed a more pronounced initial burst release from microparticles with high drug loading.