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. 2017 Jan 30;12(1):e0170203. doi: 10.1371/journal.pone.0170203

Fig 1. PIC1 inhibition of MPO peroxidase activity in CF sputum sol samples assayed by TMB.

Fig 1

(A) MPO activity, ± PIC1, in a CF sputum sol at baseline and after addition neutrophils (PMN), killed P. aeruginosa (P. aerug) or heat-aggregated IgG (Agg IgG). (B) PIC1 (7.5 mM) inhibition of MPO activity in 14 CF sputum samples. (C) A dose-response titration of PIC1 inhibition of MPO activity for a CF sputum sol with moderate baseline MPO activity (n = 3). Data are means of independent experiments ±SEM. (D) MPO activity of CF sol in the presence of PIC1 (7.5 mM) or acidified with HCl.