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. 2017 Jan 25;12:855–869. doi: 10.2147/IJN.S122678

Figure 8.

Figure 8

Cell viability and ROS levels in A549 cells treated with various doses of Cur and PPHC without and in the presence of ROS inhibitor NAC (5 mM).

Notes: (A) Cell viability of A549 cells treated with various doses of Cur and PPHC without and with NAC for 24 h. (B) The percentage of cell positivity from a DCFH-DA assay for A549 cells after 24 h treatment with Cur and PPHC (Ccur =20 μg/mL) in the absence of and presence of NAC (5 mM). The data are shown as mean ± standard error of mean (n=3). *P<0.05, **P<0.01, and ***P<0.001 for significance difference.

Abbreviations: ROS, reactive oxygen species; Cur, curcumin; PPH, 4-(hydroxymethyl) phenylboronic acid-modified PEG-grafted poly (acrylic acid) polymer; PPHC, curcumin-coordinated reactive oxygen species-responsive nanoparticle; NAC, N-acetyl-cysteine; DCFH-DA, 2,7-dichlorodihydrofluoroscein diacetate; DMSO, dimethyl sulfoxide.