| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Antibodies | ||
| Rabbit polyclonal anti-14-3-3-beta (clone C-20) | Santa Cruz | Cat#sc-628; RRID: AB_630818 |
| Mouse monoclonal anti-14-3-3-epsilon (clone 8C3) | Santa Cruz | Cat#sc-23957; RRID: AB_626619 |
| Rabbit polyclonal anti-14-3-3-zeta (clone C-16) | Santa Cruz | Cat#sc-1019; RRID: AB_2218378 |
| Rabbit polyclonal anti-4E-BP1 | Cell Signaling Technology | Cat#9452; RRID: AB_331692 |
| Rabbit monoclonal anti-phospho-4E-BP1 (Ser65) (clone 174A9) | Cell Signaling Technology | Cat#9456; RRID: AB_823413 |
| Rabbit polyclonal anti-phospho-4E-BP1 (Thr37/46) | Cell Signaling Technology | Cat#9459; RRID: AB_2262165 |
| Rabbit polyclonal anti-53BP1 | Cell Signaling Technology | Cat#4937; RRID: AB_10694558 |
| Rabbit polyclonal anti-phospho-ACC (Ser79) | Cell Signaling Technology | Cat#3661; RRID: AB_330337 |
| Rabbit monoclonal anti-ACC1 (clone EP687Y) | Epitomics | Cat#1768-1; RRID: AB_598134 |
| Rabbit monoclonal anti-ACVRL1 (clone EPR4074) | Epitomics | Cat#2940-1; RRID: AB_2222593 |
| Mouse monoclonal anti-AIB1 (clone 34) | BD Biosciences | Cat#611105; RRID: AB_2151198 |
| Rabbit monoclonal anti-Akt (pan) (clone C67E7) | Cell Signaling Technology | Cat#4691; RRID: AB_915783 |
| Rabbit polyclonal anti-Akt | Cell Signaling Technology | Cat#9272; RRID: AB_329827 |
| Rabbit polyclonal anti-phospho-Akt (Ser473) | Cell Signaling Technology | Cat#9271; RRID: AB_329825 |
| Rabbit polyclonal anti-phospho-Akt (Thr308) | Cell Signaling Technology | Cat#9275; RRID: AB_329828 |
| Mouse monoclonal anti-alpha-catenin (clone 1G5) | Calbiochem | Cat#CA1030; RRID: AB_2243846 |
| Rabbit polyclonal anti-AMPK-alpha | Cell Signaling Technology | Cat#2532; RRID: AB_330331 |
| Rabbit monoclonal anti-phospho-AMPK-alpha (Thr172) (clone 40H9) | Cell Signaling Technology | Cat#2535; RRID: AB_331250 |
| Rabbit polyclonal anti-Annexin-I | Invitrogen | Cat#71-3400; RRID: AB_2533983 |
| Mouse monoclonal anti-Annexin-VII (clone 5) | BD Biosciences | Cat#610668; RRID: AB_397995 |
| Rabbit monoclonal anti-AR (clone EP670Y) | Epitomics | Cat#1852-1; RRID: AB_764443 |
| Mouse monoclonal anti-B-Raf (clone F-7) | Santa Cruz | Cat#sc-5284; RRID: AB_626760 |
| Rabbit polyclonal anti-phospho-Bad (Ser112) | Cell Signaling Technology | Cat#9291; RRID: AB_331418 |
| Rabbit monoclonal anti-BAK (clone Y164) | Epitomics | Cat#1542-1; RRID: AB_562051 |
| Rabbit polyclonal anti-BAX | Cell Signaling Technology | Cat#2772; RRID: AB_10695870 |
| Mouse monoclonal anti-BCL-2 | Dako | Cat#M0887; RRID: AB_2064429 |
| Rabbit monoclonal anti-Bcl-X (clone E18) | Epitomics | Cat#1018-1; RRID: AB_289586 |
| Rabbit polyclonal anti-Bcl-xL | Cell Signaling Technology | Cat#2762; RRID: AB_10694844 |
| Goat polyclonal anti-Beclin (clone D-18) | Santa Cruz | Cat#sc-10086; RRID: AB_2259076 |
| Rabbit polyclonal anti-beta-Catenin | Cell Signaling Technology | Cat#9562; RRID: AB_331149 |
| Rabbit monoclonal anti-BID (clone Y8) | Epitomics | Cat#1008-1; RRID: AB_365478 |
| Rabbit monoclonal anti-BIM (clone Y36) | Epitomics | Cat#1036-1; RRID: AB_347632 |
| Rabbit polyclonal anti-phospho-c-Jun (Ser73) | Cell Signaling Technology | Cat#9164; RRID: AB_330893 |
| Rabbit monoclonal anti-c-KIT (clone YR145) | Epitomics | Cat#1522-1; RRID: AB_731513 |
| Mouse monoclonal anti-c-Met (clone 25H2) | Cell Signaling Technology | Cat#3127; RRID: AB_2181554 |
| Rabbit monoclonal anti-phospho-c-Met (Tyr1234/1235) (clone 3D7) | Cell Signaling Technology | Cat#3129; RRID: AB_561175 |
| Rabbit polyclonal anti-c-Myc | Cell Signaling Technology | Cat#9402; RRID: AB_10693752 |
| Rabbit polyclonal anti-c-Myc (clone N-262) | Santa Cruz | Cat#sc-764; RRID: AB_631276 |
| Rabbit monoclonal anti-c-Raf (clone AM223) | Millipore | Cat#05-739; RRID: AB_309953 |
| Rabbit monoclonal anti-phospho-c-Raf (Ser338) (clone 56A6) | Cell Signaling Technology | Cat#9427; RRID: AB_2067317 |
| Rabbit monoclonal anti-Caspase-3- (Active) (clone E83-77) | Epitomics | Cat#1476-1; RRID: AB_562063 |
| Rabbit polyclonal anti-Caspase-7 (cleaved D198) | Cell Signaling Technology | Cat#9491; RRID: AB_2068144 |
| Rabbit polyclonal anti-Caspase-9 (cleaved D330) | Cell Signaling Technology | Cat#9501; RRID: AB_331424 |
| Rabbit polyclonal anti-Caveolin-1 | Cell Signaling Technology | Cat#3238; RRID: AB_10699017 |
| Mouse monoclonal anti-CD31 | Dako | Cat#M0823; RRID: AB_2114471 |
| Mouse monoclonal anti-CD49B (clone 2) | BD Biosciences | Cat#611016; RRID: AB_398329 |
| Rabbit polyclonal anti-CDK1 | Cell Signaling Technology | Cat#9112; RRID: AB_10693432 |
| Rabbit polyclonal anti-Chk1 | Cell Signaling Technology | Cat#2345; RRID: AB_10693648 |
| Rabbit monoclonal anti-phospho-Chk1 (Ser345) (clone 133D3) | Cell Signaling Technology | Cat#2348; RRID: AB_2080326 |
| Mouse monoclonal anti-Chk2 (clone 1C12) | Cell Signaling Technology | Cat#3440; RRID: AB_2229490 |
| Rabbit monoclonal anti-phospho-Chk2 (Thr68) (clone C13C1) | Cell Signaling Technology | Cat#2197; RRID: AB_2080501 |
| Rabbit polyclonal anti-cIAP-1/HIAP-2 | Millipore | Cat#07-759; RRID: AB_11212879 |
| Rabbit polyclonal anti-Claudin-7 | Novus Biologicals | Cat#NB100-91714; RRID: AB_1216502 |
| Rabbit polyclonal anti-Collagen-VI (clone H-200) | Santa Cruz | Cat#SC-20649; RRID: AB_2083098 |
| Rabbit monoclonal anti-COX-2 (clone EP1978Y) | Epitomics | Cat#2169-1; RRID: AB_991710 |
| Rabbit monoclonal anti-Cyclin-B1 (clone Y106) | Epitomics | Cat#1495-1; RRID: AB_562272 |
| Rabbit polyclonal anti-Cyclin-D1 (clone M-20) | Santa Cruz | Cat#sc-718; RRID: AB_2070436 |
| Mouse monoclonal anti-Cyclin-E1 (clone HE12) | Santa Cruz | Cat#sc-247; RRID: AB_627357 |
| Rabbit monoclonal anti-DJ-1/PARK7 (clone EP2815Y) | Abcam | Cat#ab76008; RRID: AB_1310549 |
| Rabbit polyclonal anti-Dvl3 | Cell Signaling Technology | Cat#3218; RRID: AB_10694060 |
| Rabbit polyclonal anti-E-Cadherin | Cell Signaling Technology | Cat#4065; RRID: AB_2076803 |
| Rabbit monoclonal anti-E-Cadherin (clone 24E10) | Cell Signaling Technology | Cat#3195; RRID: AB_10694492 |
| Rabbit polyclonal anti-eEF2 | Cell Signaling Technology | Cat#2332; RRID: AB_10693546 |
| Rabbit polyclonal anti-eEF2K | Cell Signaling Technology | Cat#3692; RRID: AB_10694413 |
| Rabbit polyclonal anti-EGFR (clone 1005) | Santa Cruz | Cat#SC-03; RRID: AB_631420 |
| Rabbit polyclonal anti-EGFR | Cell Signaling Technology | Cat#2232; RRID: AB_823483 |
| Rabbit polyclonal anti-phospho-EGFR (Tyr1068) | Cell Signaling Technology | Cat#2234; RRID: AB_331701 |
| Rabbit monoclonal anti-phospho-EGFR (Tyr1173) (E124) | Epitomics | Cat#1124; RRID: AB_344895 |
| Rabbit polyclonal anti-phospho-EGFR_pY992 | Cell Signaling Technology | Cat#2235; RRID: AB_331709 |
| Rabbit polyclonal anti-eIF4E | Cell Signaling Technology | Cat#9742; RRID: AB_823488 |
| Rabbit polyclonal anti-eIF4G | Cell Signaling Technology | Cat#2498; RRID: AB_10692643 |
| Rabbit monoclonal anti-ER-alpha (clone SP1) | Lab Vision | Cat#RM-9101-S; RRID: AB_149901 |
| Rabbit monoclonal anti-phospho-ER-alpha (Ser118) (clone E91) | Epitomics | Cat#1091-1; RRID: AB_562111 |
| Mouse monoclonal anti-ERCC1 (clone 8F1) | Lab Vision | Cat#MS-671-P0; RRID: AB_143360 |
| Rabbit monoclonal anti-FAK (clone EP695Y) | Epitomics | Cat#1700-1; RRID: AB_562113 |
| Rabbit monoclonal anti-Fibronectin (clone F14) | Epitomics | Cat#1574-1; RRID: AB_562115 |
| Rabbit monoclonal anti-FoxM1 (clone D12D5) | Cell Signaling Technology | Cat#5436; RRID: AB_10692483 |
| Rabbit polyclonal anti-FOXO3a | Cell Signaling Technology | Cat#9467; RRID: AB_10693643 |
| Rabbit monoclonal anti-FOXO3a (clone 75D8) | Cell Signaling Technology | Cat#2497; RRID: AB_836876 |
| Rabbit polyclonal anti-phospho-FOXO3a (Ser318/321) | Cell Signaling Technology | Cat#9465; RRID: AB_2106498 |
| Rabbit monoclonal anti-Gab2 (clone 26B6) | Cell Signaling Technology | Cat#3239; RRID: AB_10698601 |
| Mouse monoclonal anti-GATA3 (clone L50-823) | BD Biosciences | Cat#558686; RRID: AB_2108590 |
| Mouse monoclonal anti-GSK3-alpha-beta (clone 0011-A) | Santa Cruz | Cat#sc-7291; RRID: AB_2279451 |
| Rabbit polyclonal anti-phospho-GSK3-alpha-beta (Ser21/9) | Cell Signaling Technology | Cat#9331; RRID: AB_329830 |
| Rabbit polyclonal anti-phospho-GSK3 (Ser9) | Cell Signaling Technology | Cat#9336; RRID: AB_331405 |
| Mouse monoclonal anti-HER2 | Lab Vision | Cat#MS-325-P1; RRID: AB_61444 |
| Rabbit polyclonal anti-phospho-HER2 (Tyr1248) | Upstate (Millipore) | Cat#06-229; RRID: AB_310076 |
| Rabbit polyclonal anti-HER3 (clone C-17) | Santa Cruz | Cat#sc-285; RRID: AB_2099723 |
| Rabbit monoclonal anti-phospho-HER3 (Tyr1289) (clone 21D3) | Cell Signaling Technology | Cat#4791; RRID: AB_2099708 |
| Rabbit polyclonal anti-IGF-1R-beta | Cell Signaling Technology | Cat#3027; RRID: AB_2122378 |
| Rabbit polyclonal anti-IGFBP2 | Cell Signaling Technology | Cat#3922; RRID: AB_10691844 |
| Goat polyclonal anti-INPP4B (clone N-20) | Santa Cruz | Cat#SC-12318; RRID: AB_2126126 |
| Rabbit polyclonal anti-IRS1 | Millipore | Cat#06-248; RRID: AB_2127890 |
| Rabbit monoclonal anti-phospho-JNK/SAPK (Thr183/Tyr185) (clone 81E11) | Cell Signaling Technology | Cat#4668; RRID: AB_823588 |
| Rabbit polyclonal anti-JNK2 | Cell Signaling Technology | Cat#4672; RRID: AB_10695599 |
| Mouse monoclonal anti-k-Ras (clone F234) | Santa Cruz | Cat#sc-30; RRID: AB_627865 |
| Rabbit polyclonal anti-Lck | Cell Signaling Technology | Cat#2752; RRID: AB_10691548 |
| Rabbit monoclonal anti-phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (clone 197G2) | Cell Signaling Technology | Cat#4377; RRID: AB_331775 |
| Rabbit monoclonal anti-MEK1 (clone Y77) | Epitomics | Cat#1235-1; RRID: AB_562310 |
| Rabbit monoclonal anti-phospho-MEK1 (Ser217/221) (clone 41G9) | Cell Signaling Technology | Cat#9154; RRID: AB_2138017 |
| Mouse monoclonal anti-MGMT (clone MT3.1) | Millipore | Cat#MAB16200; RRID: AB_2281919 |
| Mouse monoclonal anti-MIG-6 | Sigma-Aldrich | Cat#WH0054206M1; RRID: AB_1841511 |
| Rabbit monoclonal anti-Mre11 (clone 31H4) | Cell Signaling Technology | Cat#4847; RRID: AB_10693469 |
| Mouse monoclonal anti-MSH2 (clone 3A2) | Cell Signaling Technology | Cat#2850; RRID: AB_2144797 |
| Rabbit polyclonal anti-MSH6 | Novus Biologicals | Cat#22030002; RRID: AB_2266534 |
| Rabbit monoclonal anti-mTOR (clone 7C10) | Cell Signaling Technology | Cat#2983; RRID: AB_2105622 |
| Rabbit polyclonal anti-phospho-mTOR (Ser2448) | Cell Signaling Technology | Cat#2971; RRID: AB_330970 |
| Rabbit polyclonal anti-MYH11 | Novus Biologicals | Cat#21370002; RRID: AB_2147162 |
| Rabbit polyclonal anti-N-Cadherin | Cell Signaling Technology | Cat#4061; RRID: AB_10694647 |
| Mouse monoclonal anti-N-Ras (clone F155) | Santa Cruz | Cat#sc-31; RRID: AB_628041 |
| Rabbit polyclonal anti-phospho-NDRG1 (Thr346) | Cell Signaling Technology | Cat#3217; RRID: AB_2150174 |
| Rabbit monoclonal anti-phospho-NF-kB-p65 (Ser536) | Cell Signaling Technology | Cat#3033; RRID: AB_331284 |
| Rabbit polyclonal anti-NF2 | SDI / Novus | Cat#2271.00.02; RRID: AB_2298264 |
| Rabbit monoclonal anti-Notch1 (clone C44H11) | Cell Signaling Technology | Cat#3268; RRID: AB_1264224 |
| Rabbit polyclonal anti-Notch3 (clone M-134) | Santa Cruz | Cat#sc-5593; RRID: AB_2151246 |
| Rabbit polyclonal anti-P-Cadherin | Cell Signaling Technology | Cat#2130; RRID: AB_10693468 |
| Rabbit polyclonal anti-p21 (clone C-19) | Santa Cruz | Cat#sc-397; RRID: AB_632126 |
| Rabbit monoclonal anti-p27/Kip1 (clone Y236) | Epitomics | Cat#1591-1; RRID: AB_562357 |
| Rabbit polyclonal anti-phospho-p27/Kip1 (Thr157) | R&D Systems | Cat#AF1555; RRID: AB_354857 |
| Rabbit polyclonal anti-phospho-p27/KIP 1 (Thr198) | Abcam | Cat#ab64949; RRID: AB_1142099 |
| Rabbit polyclonal anti-p38 MAPK | Cell Signaling Technology | Cat#9212; RRID: AB_330713 |
| Rabbit polyclonal anti-phospho-p38 MAPK (Thr180/Tyr182) | Cell Signaling Technology | Cat#9211; RRID: AB_331641 |
| Rabbit polyclonal anti-p53 | Cell Signaling Technology | Cat#9282; RRID: AB_10693944 |
| Rabbit monoclonal anti-p70S6K (clone E343) | Epitomics | Cat#1494-1; RRID: AB_562325 |
| Rabbit polyclonal anti-phospho-p70S6K (Thr389) | Cell Signaling Technology | Cat#9205; RRID: AB_330944 |
| Rabbit polyclonal anti-phospho-p90RSK (Thr359/Ser363) | Cell Signaling Technology | Cat#9344; RRID: AB_331650 |
| Mouse monoclonal anti-PARP (cleaved D214) (clone 19F4) | Cell Signaling Technology | Cat#9546; RRID: AB_2160593 |
| Rabbit monoclonal anti-Paxillin (clone Y113) | Epitomics | Cat#1500-1; RRID: AB_562188 |
| Mouse monoclonal anti-PCNA (clone PC10) | Abcam | Cat#ab29; RRID: AB_303394 |
| Rabbit polyclonal anti-PDCD4 | Rockland | Cat#600-401-965; RRID: AB_828370 |
| Rabbit polyclonal anti-PDK1 | Cell Signaling Technology | Cat#3062; RRID: AB_10695863 |
| Rabbit polyclonal anti-phospho-PDK1 (Ser241) | Cell Signaling Technology | Cat#3061; RRID: AB_2161311 |
| Rabbit polyclonal anti-PEA15 | Cell Signaling Technology | Cat#2780; RRID: AB_2268149 |
| Rabbit polyclonal anti-phospho-PEA15 (Ser116) | Invitrogen | Cat#44-836G; RRID: AB_2533775 |
| Rabbit polyclonal anti-PI3K-p110-alpha | Cell Signaling Technology | Cat#4255; RRID: AB_10695395 |
| Rabbit polyclonal anti-PI3K_p85 | Millipore | Cat#06-195; RRID: AB_310069 |
| Mouse monoclonal anti-PKC-alpha (clone M4) | Millipore | Cat#05-154; RRID: AB_2284233 |
| Rabbit polyclonal anti-phospho-PKC-alpha (Ser657) | Millipore | Cat#06-822; RRID: AB_310258 |
| Rabbit polyclonal anti-phospho-PKC-delta (Ser664) | Millipore | Cat#07-875; RRID: AB_568868 |
| Rabbit polyclonal anti-phospho-PKC-pan-betaII (Ser660) | Cell Signaling Technology | Cat#9371; RRID: AB_2168219 |
| Rabbit monoclonal anti-PR (clone YR85) | Epitomics | Cat#1483-1; RRID: AB_562201 |
| Rabbit polyclonal anti-phospho-PRAS40 (Thr246) | Biosource | Cat#441100G; RRID: AB_2533573 |
| Rabbit polyclonal anti-PTCH | SDI | Cat#21130002; RRID: AB_876276 |
| Rabbit polyclonal anti-PTEN | Cell Signaling Technology | Cat#9552; RRID: AB_10694066 |
| Rabbit polyclonal anti-Rab11 | Cell Signaling Technology | Cat#3539; RRID: AB_2253210 |
| Rabbit polyclonal anti-Rab25 | Covance (custom antibody services) | N/A |
| Mouse monoclonal anti-Rad50 (clone 13B3/2C6) | Millipore | Cat#05-525; RRID: AB_309782 |
| Mouse polyclonal anti-Rad51 | Chem Biotech | Cat#na 71 |
| Rabbit monoclonal anti-Raptor (24C12) | Cell Signaling Technology | Cat#2280; RRID: AB_10694695 |
| Mouse monoclonal anti-Rb (clone 4H1) | Cell Signaling Technology | Cat#9309; RRID: AB_823629 |
| Rabbit polyclonal anti-phospho-Rb (Ser807/811) | Cell Signaling Technology | Cat#9308; RRID: AB_331472 |
| Rabbit polyclonal anti-RBM15 | Novus Biologicals | Cat#21390002; RRID: AB_2175759 |
| Rabbit monoclonal anti-Rictor (clone 53A2) | Cell Signaling Technology | Cat#2114; RRID: AB_10694641 |
| Rabbit monoclonal anti-phospho-Rictor (Thr1135) (clone D30A3) | Cell Signaling Technology | Cat#3806; RRID: AB_10557237 |
| Rabbit polyclonal anti-phospho-S6 (Ser235/236) | Cell Signaling Technology | Cat#2211; RRID: AB_331679 |
| Rabbit polyclonal anti-phospho-S6 (Ser240/244) | Cell Signaling Technology | Cat#2215; RRID: AB_331682 |
| Mouse monoclonal anti-SCD1 (clone CD.E10) | Santa Cruz | Cat#sc-58420; RRID: AB_785599 |
| Mouse monoclonal anti-SF2 (clone 96) | Invitrogen | Cat#32-4500; RRID: AB_2533079 |
| Mouse monoclonal anti-Smac/Diablo | Cell Signaling Technology | Cat#2954; RRID: AB_10694396 |
| Rabbit monoclonal anti-Smad1 (clone EP565Y) | Epitomics | Cat#1649-1; RRID: AB_562224 |
| Rabbit monoclonal anti-Smad3 (clone EP568Y) | Epitomics | Cat#1735-1; RRID: AB_598188 |
| Mouse polyclonal anti-Smad4 (clone B-8) | Santa Cruz | Cat#sc-7966; RRID: AB_627905 |
| Mouse polyclonal anti-Snail (clone L70G2) | Cell Signaling Technology | Cat#3895; RRID: AB_2191759 |
| Mouse monoclonal anti-Src (clone GD11) | Millipore | Cat#05-184; RRID: AB_2302631 |
| Rabbit polyclonal anti-phospho-Src (Tyr416) | Cell Signaling Technology | Cat#2101; RRID: AB_331697 |
| Rabbit polyclonal anti-phospho-Src (Tyr527) | Cell Signaling Technology | Cat#2105; RRID: AB_331034 |
| Rabbit polyclonal anti-phospho-STAT3 (Tyr705) | Cell Signaling Technology | Cat#9131; RRID: AB_331586 |
| Rabbit monoclonal anti-STAT5-alpha (E289) | Epitomics | Cat#1289-1; RRID: AB_562347 |
| Rabbit monoclonal anti-Stathmin (clone EP1573Y) | Epitomics | Cat#1972-1; RRID: AB_991829 |
| Mouse monoclonal anti-Syk (clone 4D10) | Santa Cruz | Cat#sc-1240; RRID: AB_628308 |
| Mouse monoclonal anti-Tau (clone 5E2) | Millipore | Cat#05-348; RRID: AB_309687 |
| Rabbit polyclonal anti-TAZ | Cell Signaling Technology | Cat#2149; RRID: AB_823657 |
| Rabbit polyclonal anti-phospho-TAZ (Ser89) | Santa Cruz | Cat#sc-17610; RRID: AB_671263 |
| Rabbit polyclonal anti-TIGAR | Epitomics | Cat#S1711; RRID: AB_10638379 |
| Mouse monoclonal anti-Transglutaminase II | Lab Vision | Cat#MS-224-P1; RRID: AB_62205 |
| Rabbit polyclonal anti-TFRC | Novus Biologicals | Cat#22500002; RRID: AB_10004660 |
| Rabbit polyclonal anti-TSC1 | Cell Signaling Technology | Cat#4906; RRID: AB_10695257 |
| Rabbit monoclonal anti-TTF1 (clone EP1584Y) | Epitomics | Cat#2044-1; RRID: AB_1267367 |
| Rabbit monoclonal anti-Tuberin (clone Y320) | Epitomics | Cat#1613-1; RRID: AB_562354 |
| Rabbit polyclonal anti-VASP | Cell Signaling Technology | Cat#3112; RRID: AB_10693778 |
| Rabbit monoclonal anti-VEGFR2 (clone 55B11) | Cell Signaling Technology | Cat#2479; RRID: AB_2212507 |
| Mouse monoclonal anti-VHL (clone Ig32) | BD Biosciences | Cat#556347; RRID: AB_396376 |
| Rabbit polyclonal anti-XIAP | Cell Signaling Technology | Cat#2042; RRID: AB_2214868 |
| Rabbit polyclonal anti-XRCC1 | Cell Signaling Technology | Cat#2735; RRID: AB_2218471 |
| Rabbit polyclonal anti-YAP (clone H-125) | Santa Cruz | Cat#sc-15407; RRID: AB_2273277 |
| Rabbit polyclonal anti-phospho-YAP (Ser127) | Cell Signaling Technology | Cat#4911; RRID: AB_2218913 |
| Rabbit polyclonal anti-YB-1 | SDI / Novus | Cat#1725.00.02; RRID: AB_936227 |
| Rabbit monoclonal anti-phospho-YB-1 (Ser102) (clone C34A2) | Cell Signaling Technology | Cat#2900; RRID: AB_2219273 |
| Mouse monoclonal anti-beta-Actin (clone C4) | Santa Cruz | Cat#SC-47778; RRID: AB_626632 |
| Mouse monoclonal alpha-Tubulin (clone B-5-1-2) | Invitrogen | Cat#322500; RRID: AB_2533071 |
| Mouse monoclonal anti-Hsp90 (clone 68) | Transduction Laboratories | Cat#H38220; RRID: AB_397798 |
| HRP Donkey polyclonal anti-mouse | Jackson Immunoresearch | Cat#715-035-150; RRID: AB_2340770 |
| HRP Donkey polyclonal anti-rabbit | Jackson Immunoresearch | Cat#711-035-152; RRID: AB_10015282 |
| Chemicals, Peptides, and Recombinant Proteins | ||
| AZD8055 | Selleck | Cat#S1555 |
| GSK690693 | Selleck | Cat#S1113 |
| BEZ235 | Selleck | Cat#S1009 |
| PD173074 | Selleck | Cat#S1264 |
| GSK1120212 | Selleck | Cat#S2673 |
| AZD7762 | Selleck | Cat#S1532 |
| KX2-391 | Selleck | Cat#S2700 |
| PF4708671 | Selleck | Cat#S2163 |
| VX-702 | Selleck | Cat#S6005 |
| DMEM | GIBCO | Cat#11965-118 |
| RPMI | GIBCO | Cat#11875-119 |
| Fetal Bovine Serum | GIBCO | Cat#10437 |
| HGF | GIBCO | Cat#PHG0254 |
| FGF-alpha | GIBCO | Cat#PHG0014 |
| Insulin | Sigma | Cat#IO516-5ML |
| IGF | GIBCO | Cat#PHG0078 |
| NRG-1 | R&D Systems | Cat#5898-R |
| EGF | GIBCO | Cat#PHG0311 |
| cOmplete protease inhibitor cocktail | Roche Applied Science | Cat# 4693116001 |
| phosSTOP phosphatase inhibitor cocktail | Roche Applied Science | Cat# 4906845001 |
| Critical Commercial Assays | ||
| SuperSignal West Pico Chemiluminescent HRP Substrate Kit | Thermofisher Scientific | Cat#34080 |
| Pierce BCA Protein Assay | Thermofisher Scientific | Cat#23225 |
| Deposited Data | ||
| RPPA data | This paper | Data S1 and S2 |
| Experimental Models: Cell Lines | ||
| Human: MCF7 cells | ATCC: HTB-22 | Cat#HTB-22; RRID:CVCL_0031 |
| Human: UACC812 cells | ATCC: CRL-1897 | Cat#CRL-1897; RRID:CVCL_1781 |
| Human: BT20 cells | ATCC: HTB-19 | Cat#HTB-19; RRID:CVCL_0178 |
| Human: BT549 cells | ATCC: HTB-122 | Cat#HTB-122; RRID:CVCL_1092 |
| Software and Algorithms | ||
| Scripts for: identification of changes under kinase inhibition, network learning and assessment of network learning performance | This paper (see STAR Methods for details) | https://github.com/Steven-M-Hill/causal-signaling-networks-CellSystems2016 |
| MATLAB R2012a | MathWorks, Inc. | http://www.mathworks.com |
| DataRail | Saez-Rodriguez et al., 2008 | https://code.google.com/archive/p/sbpipeline/ |
| Cytoscape | Shannon et al., 2003 | http://www.cytoscape.org/ |
| Joint Network Inference (modified version used in this paper; script available on github, see above) | Oates et al., 2014 | http://dx.doi.org/10.1214/14-AOAS761 |
| Supercurve | Coombes et al., 2012 | http://bioinformatics.mdanderson.org/Software/supercurve/ |
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