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. Author manuscript; available in PMC: 2017 Jan 30.
Published in final edited form as: Nat Genet. 2016 Sep 26;48(11):1303–1312. doi: 10.1038/ng.3668

Figure 2. Allelic spectrum of cardiometabolic trait variants.

Figure 2

(a) For each variant surpassing the genome-wide threshold in this study, the effect size (measured in standard deviations) is plotted as a function of the minor allele frequency proportion (MAF%). Loci discovered in this study are plotted with larger symbols. Associations for HDL (black) and PLT (purple) for which novel variants were discovered are shown. The dotted line represents the curve for 80% power with a sample size of 31,749 (for HDL) and an alpha of 8.31x10–9. The power line for PLT (sample size 31,555) is similar and therefore not shown here. (b) Plot of smallest detectable effect size for a range of MAF%. Power calculations were performed for 4 traits of different trait groups and with different sample sizes: IL6, HOMA-B, LDL, and HGB.