Figure 2.

Multiple alignment of TPC1 sequence from the UniProt database.⁸⁸ (a) Clustal-Omega alignment⁸⁹ between TPC1 sequences of Homo sapiens, Mus musculus and Rattus norvergicus. *(asterisk) indicates positions which have a single, fully conserved residue, :(colon) indicates conservation between groups of strongly similar properties - scoring > 0.5 in the Gonnet PAM 250 matrix, and . (period) indicates conservation between groups of weakly similar properties - scoring =< 0.5 in the Gonnet PAM 250 matrix. (b) Percent identity matrix derived from the alignment.