Table 3. Top SNP Clusters From Systolic Blood Pressure and Diastolic Blood Pressure Meta-Analyses in EAGLE for Sex-Combined Data Set.

Time Frame	Marker Name	Allele	CHR	POS	MAF	Gene	Beta (95% CI)	P Value	Direction	ICBP p	N Effective
Systolic blood pressure
Prepubertal	rs1563894	A/G	15	66422829	0.19	ITGA11	−0.093 (−0.126, −0.060)	2.86E-08*	−−−−−	0.46	10 090
Pubertal	rs3735398	A/G	7	36412646	0.12	ANLN	0.116 (0.073,0.159)	1.28E-07	+++++	0.75	8423
	rs3787159	T/C	20	56252573	0.46	PPP4R1L	−0.064 (−0.091, −0.037)	8.76E-06	−−+−−	0.46	8423
	rs9667878	T/C	11	5180326	0.22	OR51V1	0.135 (0.0740,0.196)	9.74E-06	+++++	1.00	8423
Postpubertal	rs1010366	T/C	7	7196351	0.39	C1GALT1	0.098 (0.057,0.139)	3.31E-06	−++	0.90	5176
	rs4538187	A/G	2	63957245	0.16	UGP2	0.102 (0.057,0.147)	5.96E-06	+++	0.70	5176
	rs3901287	A/T	8	23240509	0.28	LOXL2	0.108 (0.059,0.157)	1.24E-05	+++	0.68	5176
Diastolic blood pressure
Prepubertal	rs241264	T/C	1	4518898	0.31	Between LOC284661 and AJAP1	−0.082 (−0.0120, −0.043)	2.95E-05	−−−−−	0.48	10 090
	rs1714524	T/C	3	159755790	0.44	LOC100996447	0.154 (0.081,0.227)	8.32E-05	−−−−+	0.99	10 090
	rs16875222	A/T	8	107955966	0.11	Near ABRA, OXR1	−0.119 (−0.179, −0.060)	8.21E-05	−−−−−	0.72	8423
	rs12237240	T/G	9	28329306	0.19	LINGO2	0.068 (0.034,0.102)	8.71E-05	++−+−	0.89	8423
	rs1387977	T/G	12	71307607	0.14	TRHDE	0.127 (0.064,0.190)	6.92E-05	++−++	0.90	8423
Postpubertal	rs6949619	T/C	7	24396900	0.19	Near NPY	−0.092 (−0.133, −0.051)	1.13E-05	−−−	0.45	5176
	rs229038	C/G	21	27127300	0.22	ADAMTS1	0.213 (0.115,0.311)	2.26E-05	+++	0.77	5176

Bold text highlights SNPs (P<5×10⁻³) represented in regional association plots shown in Figures VII–IX in the Data Supplement. Beta values are in terms of Z-scores, the number of standard deviations away from the mean. CHR indicates chromosome; MAF, minor allele frequency; and POS, position.

^*SNPs which have reached genome-wide levels of significance (P<5×10⁻⁸).