Table 2.
Primary outcome of FEV1 slope comparisons
| FEV1 slope (95% CI), mL/year | p value | |
|---|---|---|
| Baseline smokers | ||
| Immediate ART (n=135) | −32·9 (−58·5 to −7·4) | ·· |
| Deferred ART (n=155) | −29·7 (−54·3 to −5·0) | ·· |
| Difference | −3·3 (−38·8 to 32·2) | 0·86 |
| Baseline non-smokers | ||
| Immediate ART (n=383) | −27·8 (–44·2 to –11·4) | ·· |
| Deferred ART (n=353) | −22·2 (−39·6 to −4·9) | ·· |
| Difference | −5·6 (−29·4 to 18·3) | 0·65 |
| Pooled analysis adjusted for baseline smoking status | ||
| Immediate ART (n=518) | −29·1 (−42·9 to −15·4) | ·· |
| Deferred ART (n=508) | −24·5 (−38·6 to −10·3) | ·· |
| Difference | −4·7 (−24·4 to 15·1) | 0·64 |
| Pooled analysis adjusted for smoking status at each study visit | ||
| Immediate ART (n=518) | −28·8 (−42·6 to −14·9) | ·· |
| Deferred ART (n=508) | −23·6 (−37·8 to −9·3) | ·· |
| Difference | −5·2 (−25·1 to 14·6) | 0·61 |
Data are from groups of patients randomly assigned to either immediate or deferred ART initiation. ART=antiretroviral therapy.